STRAP and PBLD

Number of citations of the paper that reports this interaction (PMID 11355021)
5

Data Source:
HPRD (two hybrid)

		STRAP	PBLD
Gene Name		serine/threonine kinase receptor associated protein	phenazine biosynthesis-like protein domain containing
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane SMN Complex SMN-Sm Protein Complex	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Protein Binding Poly(A) RNA Binding	Molecular_function Protein Binding Isomerase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal SnRNP Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Biosynthetic Process Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Optic disc parameters ( 20548946) Optic disc size (disc) ( 20395239) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		24 interactors: C6orf203 CHEK2 GEMIN6 GEMIN7 MAP1B NXF1 PBLD PDPK1 RN7SL1 RNU1-1 RNU2-1 SMAD2 SMAD3 SMAD6 SMAD7 SMN1 SMURF1 SNRPB SNRPD2 SNRPD3 SNRPE SUMO4 TGFBR1 TGFBR2	7 interactors: CCDC184 EFHC2 LNX1 STRAP TCF4 TRIP13 UBC
Entrez ID		11171	64081
HPRD ID		05816	14366
Ensembl ID		ENSG00000023734	ENSG00000108187
Uniprot IDs		B0AZV0 B4DNJ6 Q9Y3F4	C9JIM0 P30039
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Spliceosomal SnRNP Assembly Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway NcRNA Metabolic Process Ribonucleoprotein Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta RNA Processing MRNA Splicing, Via Spliceosome Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway RNA Splicing, Via Transesterification Reactions Regulation Of Epithelial To Mesenchymal Transition Cellular Macromolecular Complex Assembly Cellular Component Assembly Ribonucleoprotein Complex Biogenesis RNA Splicing Cellular Response To Growth Factor Stimulus Response To Growth Factor Gene Expression MRNA Processing Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pathway-restricted SMAD Protein Phosphorylation RNA Metabolic Process Embryonic Cranial Skeleton Morphogenesis MRNA Metabolic Process Negative Regulation Of Signaling Spliceosomal Complex Assembly Enzyme Linked Receptor Protein Signaling Pathway Regulation Of BMP Signaling Pathway Histone MRNA Metabolic Process Response To Cholesterol Regulation Of Cell Morphogenesis Zygotic Specification Of Dorsal/ventral Axis Activin Receptor Signaling Pathway Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Embryonic Skeletal System Morphogenesis Mesonephros Development Kidney Development Termination Of RNA Polymerase II Transcription Negative Regulation Of Protein Phosphorylation Renal System Development Negative Regulation Of BMP Signaling Pathway	Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Epithelial To Mesenchymal Transition Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Polysaccharide Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Component Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Glucose Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Response To Transforming Growth Factor Beta Negative Regulation Of Wnt Signaling Pathway Hexose Metabolic Process Cell Cycle Process Maintenance Of DNA Repeat Elements DNA-templated Transcription, Initiation DNA Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Signal Transduction Cellular Carbohydrate Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Monosaccharide Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Hindgut Morphogenesis Embryonic Genitalia Morphogenesis Regulation Of Epithelial Cell Proliferation RNA Metabolic Process Myoblast Fate Commitment Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Gene Expression Regulation Of Wnt Signaling Pathway Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Secretory Granule Localization Gene Expression
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