TGFB2 and TGFBR2

Number of citations of the paper that reports this interaction (PMID 8106553)
43

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		TGFB2	TGFBR2
Gene Name		transforming growth factor, beta 2	transforming growth factor, beta receptor II (70/80kDa)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Axon Extracellular Matrix Platelet Alpha Granule Lumen Neuronal Cell Body	Cytosol Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex
	Molecular Function	Beta-amyloid Binding Receptor Signaling Protein Serine/threonine Kinase Activity Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Protein Binding ATP Binding Glycosaminoglycan Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding SMAD Binding Metal Ion Binding Transforming Growth Factor Beta Binding
	Biological Process	Cell Morphogenesis Cartilage Condensation Angiogenesis Eye Development Response To Hypoxia Epithelial To Mesenchymal Transition Hair Follicle Development Blood Vessel Remodeling Platelet Degranulation Heart Morphogenesis Heart Valve Morphogenesis Protein Phosphorylation Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Import Into Nucleus Cell-cell Signaling Axon Guidance Salivary Gland Morphogenesis Heart Development Blood Coagulation Cell Death Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Glial Cell Migration Response To Wounding Embryo Development Cardioblast Differentiation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Growth Cell Migration Signal Transduction By Phosphorylation Hemopoiesis Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Neutrophil Chemotaxis Hair Follicle Morphogenesis Activation Of Protein Kinase Activity Response To Progesterone Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Cell Adhesion Mediated By Integrin Wound Healing Dopamine Biosynthetic Process Odontogenesis Response To Drug Catagen Uterine Wall Breakdown Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Ossification Positive Regulation Of Cell Cycle Positive Regulation Of Heart Contraction Somatic Stem Cell Division Embryonic Digestive Tract Development Neuron Fate Commitment Neuron Development Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Immune Response Positive Regulation Of Immune Response Positive Regulation Of Cell Division Positive Regulation Of Catagen Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Face Morphogenesis Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Negative Regulation Of Cartilage Development Positive Regulation Of Activation-induced Cell Death Of T Cells Extrinsic Apoptotic Signaling Pathway Regulation Of Extracellular Matrix Organization Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Blood Vessel Development Patterning Of Blood Vessels Vasculogenesis In Utero Embryonic Development Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Tolerance Induction To Self Antigen Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Growth Plate Cartilage Chondrocyte Growth Protein Phosphorylation Receptor-mediated Endocytosis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation Smoothened Signaling Pathway Gastrulation Brain Development Heart Development Embryo Implantation Aging Response To Nutrient Positive Regulation Of Cell Proliferation Response To Mechanical Stimulus Response To Glucose Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organ Regeneration Activation Of Protein Kinase Activity Embryonic Hemopoiesis Wound Healing Regulation Of Cell Proliferation Response To Drug Myeloid Dendritic Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Response To Estrogen Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of NK T Cell Differentiation Palate Development Negative Regulation Of Cardiac Muscle Cell Proliferation Pathway-restricted SMAD Protein Phosphorylation Bronchus Morphogenesis Trachea Formation Mammary Gland Morphogenesis Lung Lobe Morphogenesis Response To Cholesterol Lens Fiber Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Molecules associated with elastic fibres Elastic fibre formation Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Platelet degranulation Platelet activation, signaling and aggregation	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs			Glycerol
Diseases
GWAS		Height ( 20881960) Pulmonary function ( 21946350)	Breast cancer ( 23535729) Migraine ( 22683712) Tonometry ( 17903302)
Protein-Protein Interactions		16 interactors: APP BMP2 CTGF DAXX DCN ENG FMOD LTBP3 PZP TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBR3 VASN VTN	44 interactors: ACVR1 ACVRL1 AP2B1 APP ARHGEF6 ARHGEF7 CBL CCNB1 CCNB2 CD44 CDK1 CLU CTNNB1 DAB2 DAXX EIF3I ENG GOPC KCNK18 NRP1 OSR1 PAK1 PDGFRA PIK3R1 PIK3R2 PML RCVRN SMAD3 SMAD4 SMAD7 SNX6 STRAP TCTEX1D4 TERT TGFB1 TGFB1I1 TGFB2 TGFB3 TGFBR1 TGFBR3 TGFBRAP1 TRAP1 TSSK1B ZFYVE9
Entrez ID		7042	7048
HPRD ID		01828	01823
Ensembl ID		ENSG00000092969	ENSG00000163513
Uniprot IDs		P61812	A3QNQ0 D2JYI1 P37173
PDB IDs		1TFG 2TGI	1KTZ 1M9Z 1PLO 2PJY 3KFD
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Epithelial To Mesenchymal Transition Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Organ Morphogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Skeletal System Development Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Anatomical Structure Morphogenesis Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Regulation Of Cartilage Development Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Phosphorus Metabolic Process Bone Development Response To Wounding Regulation Of Signal Transduction Regulation Of Collagen Metabolic Process Regulation Of Cell Differentiation Regulation Of Protein Metabolic Process Skeletal System Morphogenesis Response To Lipid Response To Hypoxia Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Cell Growth Aging	Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Tube Development Response To Wounding Regulation Of Cell Death Signaling Positive Regulation Of Phosphorylation Regulation Of Cell Differentiation Cellular Response To Stimulus Signal Transduction Cell Communication Response To Stress Regulation Of Gene Expression Regulation Of Apoptotic Process Tissue Morphogenesis Anatomical Structure Morphogenesis
Tagcloud ?		beta2 betageo cko conditional congenital crossing die dietz dysregulation eiiacre fetuses flox flper galactosidase genesis harboring lacz loeys multifunctional neuromuscular ocular organs osteoarthritis perinatal perinatally precluding resembled tagged	aaa adventitial alleles aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
Tagcloud (Difference) ?		beta2 betageo cko conditional congenital crossing die dietz dysregulation eiiacre fetuses flox flper galactosidase genesis harboring lacz loeys multifunctional neuromuscular ocular organs osteoarthritis perinatal perinatally precluding resembled tagged	aaa adventitial alleles aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
Tagcloud (Intersection) ?