TGFB2 and DCN

Number of citations of the paper that reports this interaction (PubMedID 9675033)
0

Data Source:
BioGRID (pull down)

		TGFB2	DCN
Description		transforming growth factor beta 2	decorin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Axon Extracellular Matrix Platelet Alpha Granule Lumen Neuronal Cell Body	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity	RNA Binding Protein Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding
	Biological Process	Cell Morphogenesis Skeletal System Development Cartilage Condensation Blood Vessel Development Eye Development Response To Hypoxia Kidney Development Epithelial To Mesenchymal Transition Neural Tube Closure Hair Follicle Development Blood Vessel Remodeling Heart Morphogenesis Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Outflow Tract Morphogenesis Heart Valve Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Endocardial Cushion Fusion Atrial Septum Primum Morphogenesis Neural Retina Development Activation-induced Cell Death Of T Cells Transforming Growth Factor Beta Receptor Signaling Pathway Axon Guidance Sensory Organ Development Salivary Gland Morphogenesis Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Glial Cell Migration Male Gonad Development Response To Wounding Embryo Development Ending In Birth Or Egg Hatching Cardioblast Differentiation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macrophage Cytokine Production Striated Muscle Tissue Development Cell Migration Negative Regulation Of Angiogenesis Signaling Hemopoiesis Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis Neutrophil Chemotaxis Epithelial Cell Differentiation Hair Follicle Morphogenesis Response To Progesterone Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Ascending Aorta Morphogenesis Wound Healing Regulation Of Cell Population Proliferation Dopamine Biosynthetic Process Odontogenesis Uterine Wall Breakdown Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Cell Cycle Positive Regulation Of Heart Contraction Negative Regulation Of Ras Protein Signal Transduction Somatic Stem Cell Division Embryonic Digestive Tract Development Neuron Fate Commitment Neuron Development Generation Of Neurons Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Positive Regulation Of Cellular Component Organization Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division Regulation Of Timing Of Catagen Positive Regulation Of Timing Of Catagen Positive Regulation Of Cardioblast Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Muscle Cell Proliferation Uterus Development Cardiac Epithelial To Mesenchymal Transition Face Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Negative Regulation Of Cartilage Development Pharyngeal Arch Artery Morphogenesis Secondary Palate Development Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Activation-induced Cell Death Of T Cells Cellular Response To Growth Factor Stimulus Positive Regulation Of Extracellular Matrix Disassembly Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Positive Regulation Of MiRNA Transcription Regulation Of Extracellular Matrix Organization Regulation Of Complement-dependent Cytotoxicity Substantia Propria Of Cornea Development Pericyte Cell Differentiation Cranial Skeletal System Development Negative Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Animal Organ Morphogenesis Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Macroautophagy Negative Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Fission Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways		Platelet degranulation Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs ECM proteoglycans TGFBR3 regulates TGF-beta signaling	Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs		Trabedersen
Diseases		Graft-versus-host disease Allograft rejection	Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy
GWAS		Acne (severe) ( 24927181 30542056) Appendicular lean mass ( 33097823) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Bone mineral density (hip) ( 30172743) Central corneal thickness ( 29760442 32528159) Chronic obstructive pulmonary disease ( 30804561 28166215) Chronic obstructive pulmonary disease (severe) ( 24621683) Diastolic blood pressure ( 30224653) Diffusing capacity of carbon monoxide ( 30694715) Emphysema imaging phenotypes ( 26030696) FEV1 ( 30804560) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Heel bone mineral density ( 30598549) Height ( 31562340 20881960 25429064 25282103) Hip circumference adjusted for BMI ( 34021172 25673412) Hip minimal joint space width ( 27701424) Intraocular pressure ( 29617998) Local histogram emphysema pattern ( 25006744) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Systolic blood pressure ( 30578418) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172)	Blood protein levels ( 30072576) Central corneal thickness ( 29760442 32528159) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998) Refractive error ( 32231278) Sudden cardiac arrest ( 21658281)
Interacting Genes		16 interacting genes: APP BMP2 CCN2 DCN ENG FMOD LTBP3 PZP SNCA TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBR3 VASN VTN	32 interacting genes: ADARB1 AHSG BRCA1 C1QA CCN4 COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SF1 SFTPD TGFB1 TGFB2 THBS1 TNF
Entrez ID		7042	1634
HPRD ID		01828	00501
Ensembl ID		ENSG00000092969	ENSG00000011465
Uniprot IDs		P61812 Q59EG9	P07585 Q6FH10
PDB IDs		1TFG 2TGI 4KXZ 5TX4 5TY4 6I9J 6XM2 7RCO 8DC0 8FXS 8FXV
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Binding Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Type II Transforming Growth Factor Beta Receptor Binding Regulation Of SMAD Protein Signal Transduction Extracellular Space Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Epithelial To Mesenchymal Transition Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Binding Type I Transforming Growth Factor Beta Receptor Binding Extracellular Region Mesenchymal Cell Differentiation Regulation Of Multicellular Organismal Process Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Type III Transforming Growth Factor Beta Receptor Binding Extracellular Matrix Enzyme-linked Receptor Protein Signaling Pathway Glycosaminoglycan Binding Regulation Of Cartilage Development Positive Regulation Of Developmental Process Muscle Tissue Morphogenesis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cardiac Epithelial To Mesenchymal Transition Regulation Of Locomotion Animal Organ Morphogenesis Positive Regulation Of Mesenchymal Stem Cell Proliferation Regulation Of Developmental Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Differentiation Golgi Lumen Negative Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity Positive Regulation Of Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Cell Surface Ventricular Cardiac Muscle Tissue Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization	Extracellular Matrix Extracellular Region Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Collagen Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Endoplasmic Reticulum Lumen Cellular Response To Amino Acid Stimulus Basement Membrane Collagen Type IV Trimer Response To Amino Acid Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Platelet-derived Growth Factor Binding Extracellular Space Collagen Fibril Organization Collagen Metabolic Process Collagen-activated Signaling Pathway Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Population Proliferation Enzyme-linked Receptor Protein Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Cell Motility Animal Organ Morphogenesis Regulation Of Locomotion Regulation Of Smooth Muscle Cell Proliferation Developmental Process Negative Regulation Of Multicellular Organismal Process Animal Organ Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Platelet Alpha Granule Lumen Extracellular Matrix Assembly Integrin Binding Face Morphogenesis Tissue Development Negative Regulation Of Cell Population Proliferation Fibrillar Collagen Trimer Positive Regulation Of Smooth Muscle Cell Proliferation Salivary Gland Morphogenesis Response To Xenobiotic Stimulus Cell Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Adhesion Response To Mechanical Stimulus Protease Binding
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