TGFB2 and TGFB3

Number of citations of the paper that reports this interaction (PMID 11157754)
15

Data Source:
HPRD (in vivo)

		TGFB2	TGFB3
Gene Name		transforming growth factor, beta 2	transforming growth factor, beta 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Axon Extracellular Matrix Platelet Alpha Granule Lumen Neuronal Cell Body	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface T-tubule Extracellular Matrix Platelet Alpha Granule Lumen Neuronal Cell Body
	Molecular Function	Beta-amyloid Binding Receptor Signaling Protein Serine/threonine Kinase Activity Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Protein Heterodimerization Activity Transforming Growth Factor Beta Binding
	Biological Process	Cell Morphogenesis Cartilage Condensation Angiogenesis Eye Development Response To Hypoxia Epithelial To Mesenchymal Transition Hair Follicle Development Blood Vessel Remodeling Platelet Degranulation Heart Morphogenesis Heart Valve Morphogenesis Protein Phosphorylation Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Import Into Nucleus Cell-cell Signaling Axon Guidance Salivary Gland Morphogenesis Heart Development Blood Coagulation Cell Death Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Glial Cell Migration Response To Wounding Embryo Development Cardioblast Differentiation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Growth Cell Migration Signal Transduction By Phosphorylation Hemopoiesis Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Neutrophil Chemotaxis Hair Follicle Morphogenesis Activation Of Protein Kinase Activity Response To Progesterone Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Cell Adhesion Mediated By Integrin Wound Healing Dopamine Biosynthetic Process Odontogenesis Response To Drug Catagen Uterine Wall Breakdown Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Ossification Positive Regulation Of Cell Cycle Positive Regulation Of Heart Contraction Somatic Stem Cell Division Embryonic Digestive Tract Development Neuron Fate Commitment Neuron Development Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Immune Response Positive Regulation Of Immune Response Positive Regulation Of Cell Division Positive Regulation Of Catagen Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Face Morphogenesis Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Negative Regulation Of Cartilage Development Positive Regulation Of Activation-induced Cell Death Of T Cells Extrinsic Apoptotic Signaling Pathway Regulation Of Extracellular Matrix Organization Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Activation Of MAPK Activity Response To Hypoxia In Utero Embryonic Development Platelet Degranulation Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Import Into Nucleus Salivary Gland Morphogenesis Female Pregnancy Aging Blood Coagulation Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Cell Growth Platelet Activation Extracellular Matrix Organization Positive Regulation Of Bone Mineralization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mammary Gland Development Response To Progesterone Positive Regulation Of Collagen Biosynthetic Process Response To Laminar Fluid Shear Stress Regulation Of Cell Proliferation Odontogenesis Uterine Wall Breakdown Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Ossification Involved In Bone Remodeling Cell-cell Junction Organization Positive Regulation Of DNA Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Digestive Tract Development Embryonic Neurocranium Morphogenesis Inner Ear Development Positive Regulation Of Protein Secretion Positive Regulation Of Filopodium Assembly Positive Regulation Of Cell Division Palate Development Face Morphogenesis Frontal Suture Morphogenesis Positive Regulation Of SMAD Protein Import Into Nucleus SMAD Protein Signal Transduction Detection Of Hypoxia
Pathways		Molecules associated with elastic fibres Elastic fibre formation Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Platelet degranulation Platelet activation, signaling and aggregation	Molecules associated with elastic fibres Elastic fibre formation Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Height ( 20881960) Pulmonary function ( 21946350)
Protein-Protein Interactions		16 interactors: APP BMP2 CTGF DAXX DCN ENG FMOD LTBP3 PZP TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBR3 VASN VTN	13 interactors: ACVRL1 CCL20 CHMP2A CTGF ENG FMOD LTBP3 SDC4 TGFB2 TGFBR1 TGFBR2 TGFBR3 VASN
Entrez ID		7042	7043
HPRD ID		01828	01829
Ensembl ID		ENSG00000092969
Uniprot IDs		P61812	A5YM40 B3KVH9 P10600
PDB IDs		1TFG 2TGI	1KTZ 1TGJ 1TGK 2PJY 3EO1
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Epithelial To Mesenchymal Transition Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Organ Morphogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Skeletal System Development Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Anatomical Structure Morphogenesis Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Regulation Of Cartilage Development Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Phosphorus Metabolic Process Bone Development Response To Wounding Regulation Of Signal Transduction Regulation Of Collagen Metabolic Process Regulation Of Cell Differentiation Regulation Of Protein Metabolic Process Skeletal System Morphogenesis Response To Lipid Response To Hypoxia Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Cell Growth Aging	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cartilage Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Blood Vessel Development Vasculature Development Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Angiogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Component Movement Response To Wounding Tube Development Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Chondrocyte Differentiation Blood Vessel Morphogenesis Positive Regulation Of Protein Metabolic Process Cell Migration Response To Lipid Positive Regulation Of Phosphorylation Cardiovascular System Development Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Cell Proliferation Skeletal System Morphogenesis Skeletal System Development Extracellular Matrix Constituent Secretion Regulation Of Epithelial Cell Proliferation Organ Morphogenesis Regulation Of Cell Migration Regulation Of Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Wound Healing Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation
Tagcloud ?		beta2 betageo cko conditional congenital crossing die dietz dysregulation eiiacre fetuses flox flper galactosidase genesis harboring lacz loeys multifunctional neuromuscular ocular organs osteoarthritis perinatal perinatally precluding resembled tagged	alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfa thra1 transforming transmission trios utilizing
Tagcloud (Difference) ?		beta2 betageo cko congenital crossing die dietz dysregulation eiiacre fetuses flox flper galactosidase genesis harboring lacz loeys multifunctional neuromuscular ocular organs osteoarthritis perinatal perinatally precluding resembled tagged	alleles bcl3 cleft clefts covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfa thra1 transforming transmission trios utilizing
Tagcloud (Intersection) ?		conditional