TGFB2 and FMOD

Number of citations of the paper that reports this interaction (PMID 8093006)
134

Data Source:
HPRD (in vitro)

		TGFB2	FMOD
Gene Name		transforming growth factor, beta 2	fibromodulin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Axon Extracellular Matrix Platelet Alpha Granule Lumen Neuronal Cell Body	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	Beta-amyloid Binding Receptor Signaling Protein Serine/threonine Kinase Activity Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Cell Morphogenesis Cartilage Condensation Angiogenesis Eye Development Response To Hypoxia Epithelial To Mesenchymal Transition Hair Follicle Development Blood Vessel Remodeling Platelet Degranulation Heart Morphogenesis Heart Valve Morphogenesis Protein Phosphorylation Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Import Into Nucleus Cell-cell Signaling Axon Guidance Salivary Gland Morphogenesis Heart Development Blood Coagulation Cell Death Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Glial Cell Migration Response To Wounding Embryo Development Cardioblast Differentiation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Growth Cell Migration Signal Transduction By Phosphorylation Hemopoiesis Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Neutrophil Chemotaxis Hair Follicle Morphogenesis Activation Of Protein Kinase Activity Response To Progesterone Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Cell Adhesion Mediated By Integrin Wound Healing Dopamine Biosynthetic Process Odontogenesis Response To Drug Catagen Uterine Wall Breakdown Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Ossification Positive Regulation Of Cell Cycle Positive Regulation Of Heart Contraction Somatic Stem Cell Division Embryonic Digestive Tract Development Neuron Fate Commitment Neuron Development Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Immune Response Positive Regulation Of Immune Response Positive Regulation Of Cell Division Positive Regulation Of Catagen Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Face Morphogenesis Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Negative Regulation Of Cartilage Development Positive Regulation Of Activation-induced Cell Death Of T Cells Extrinsic Apoptotic Signaling Pathway Regulation Of Extracellular Matrix Organization Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Carbohydrate Metabolic Process Transforming Growth Factor Beta Receptor Complex Assembly Pathogenesis Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process
Pathways		Molecules associated with elastic fibres Elastic fibre formation Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Platelet degranulation Platelet activation, signaling and aggregation	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome Keratan sulfate/keratin metabolism MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Height ( 20881960) Pulmonary function ( 21946350)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		16 interactors: APP BMP2 CTGF DAXX DCN ENG FMOD LTBP3 PZP TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBR3 VASN VTN	3 interactors: TGFB1 TGFB2 TGFB3
Entrez ID		7042	2331
HPRD ID		01828	02591
Ensembl ID		ENSG00000092969	ENSG00000122176
Uniprot IDs		P61812	B3KS64 Q06828 Q12833
PDB IDs		1TFG 2TGI
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Epithelial To Mesenchymal Transition Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Organ Morphogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Skeletal System Development Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Anatomical Structure Morphogenesis Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Regulation Of Cartilage Development Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Phosphorus Metabolic Process Bone Development Response To Wounding Regulation Of Signal Transduction Regulation Of Collagen Metabolic Process Regulation Of Cell Differentiation Regulation Of Protein Metabolic Process Skeletal System Morphogenesis Response To Lipid Response To Hypoxia Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Cell Growth Aging	Negative Regulation Of Macrophage Cytokine Production SMAD Protein Import Into Nucleus Positive Regulation Of Epithelial To Mesenchymal Transition Face Morphogenesis Head Morphogenesis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Salivary Gland Morphogenesis Salivary Gland Development Uterine Wall Breakdown Response To Progesterone Face Development Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Exocrine System Development Body Morphogenesis Platelet Degranulation Regulation Of Cytokine Production Involved In Immune Response Ossification Involved In Bone Remodeling Positive Regulation Of Ossification Frontal Suture Morphogenesis Tissue Remodeling Protein Import Into Nucleus Nuclear Import Positive Regulation Of Cell Division Negative Regulation Of Immune Response Digestive Tract Development Transforming Growth Factor Beta Receptor Signaling Pathway Cell Growth Digestive System Development Protein Import Gland Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Protein Localization To Nucleus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Platelet Activation Positive Regulation Of Protein Secretion Regulation Of Ossification Negative Regulation Of Cytokine Production Cell-cell Junction Organization Cranial Suture Morphogenesis Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Division Regulation Of SMAD Protein Import Into Nucleus Craniofacial Suture Morphogenesis Response To Laminar Fluid Shear Stress
Tagcloud ?		beta2 betageo cko conditional congenital crossing die dietz dysregulation eiiacre fetuses flox flper galactosidase genesis harboring lacz loeys multifunctional neuromuscular ocular organs osteoarthritis perinatal perinatally precluding resembled tagged	adenovirus albuminuria assisted clue cytoskeleton desorption diabetic dn exploring fibromodulin flight injections intraperitoneal ionization kidneys killed leucine maldi modulator nephropathy proteoglycan rad rad5 separated spots streptozotocin stz tof vectors
Tagcloud (Difference) ?		beta2 betageo cko conditional congenital crossing die dietz dysregulation eiiacre fetuses flox flper galactosidase genesis harboring lacz loeys multifunctional neuromuscular ocular organs osteoarthritis perinatal perinatally precluding resembled tagged	adenovirus albuminuria assisted clue cytoskeleton desorption diabetic dn exploring fibromodulin flight injections intraperitoneal ionization kidneys killed leucine maldi modulator nephropathy proteoglycan rad rad5 separated spots streptozotocin stz tof vectors
Tagcloud (Intersection) ?