TGFB2 and ENG

Number of citations of the paper that reports this interaction (PMID 12015308)
30

Data Source:
HPRD (in vivo, in vitro)

		TGFB2	ENG
Gene Name		transforming growth factor, beta 2	endoglin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Axon Extracellular Matrix Platelet Alpha Granule Lumen Neuronal Cell Body	Extracellular Space Nucleoplasm Cytoplasm Focal Adhesion External Side Of Plasma Membrane Cell Surface Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex Endothelial Microparticle
	Molecular Function	Beta-amyloid Binding Receptor Signaling Protein Serine/threonine Kinase Activity Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor, Cytoplasmic Mediator Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Cell Morphogenesis Cartilage Condensation Angiogenesis Eye Development Response To Hypoxia Epithelial To Mesenchymal Transition Hair Follicle Development Blood Vessel Remodeling Platelet Degranulation Heart Morphogenesis Heart Valve Morphogenesis Protein Phosphorylation Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Import Into Nucleus Cell-cell Signaling Axon Guidance Salivary Gland Morphogenesis Heart Development Blood Coagulation Cell Death Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Glial Cell Migration Response To Wounding Embryo Development Cardioblast Differentiation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Growth Cell Migration Signal Transduction By Phosphorylation Hemopoiesis Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Neutrophil Chemotaxis Hair Follicle Morphogenesis Activation Of Protein Kinase Activity Response To Progesterone Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Cell Adhesion Mediated By Integrin Wound Healing Dopamine Biosynthetic Process Odontogenesis Response To Drug Catagen Uterine Wall Breakdown Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Ossification Positive Regulation Of Cell Cycle Positive Regulation Of Heart Contraction Somatic Stem Cell Division Embryonic Digestive Tract Development Neuron Fate Commitment Neuron Development Generation Of Neurons Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Immune Response Positive Regulation Of Immune Response Positive Regulation Of Cell Division Positive Regulation Of Catagen Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Face Morphogenesis Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Negative Regulation Of Cartilage Development Positive Regulation Of Activation-induced Cell Death Of T Cells Extrinsic Apoptotic Signaling Pathway Regulation Of Extracellular Matrix Organization Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chronological Cell Aging Patterning Of Blood Vessels Vasculogenesis Response To Hypoxia Positive Regulation Of Protein Phosphorylation Negative Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Systemic Arterial Blood Pressure Cell Migration Involved In Endocardial Cushion Formation Regulation Of Transcription, DNA-templated Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Extracellular Matrix Disassembly Regulation Of Cell Adhesion Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Autophosphorylation Response To Corticosteroid Positive Regulation Of Collagen Biosynthetic Process Intracellular Signal Transduction Response To Statin Wound Healing Regulation Of Cell Proliferation Regulation Of Phosphorylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Cell Motility Negative Regulation Of Nitric-oxide Synthase Activity Cell Chemotaxis Bone Development Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Extracellular Matrix Constituent Secretion Detection Of Hypoxia Cellular Response To Mechanical Stimulus Response To Transforming Growth Factor Beta
Pathways		Molecules associated with elastic fibres Elastic fibre formation Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Height ( 20881960) Pulmonary function ( 21946350)	Metabolic syndrome ( 20694148)
Protein-Protein Interactions		16 interactors: APP BMP2 CTGF DAXX DCN ENG FMOD LTBP3 PZP TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBR3 VASN VTN	12 interactors: ACVR1 ACVR2A BMP2 BMP7 INHBA TCTEX1D4 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3
Entrez ID		7042	2022
HPRD ID		01828	00565
Ensembl ID		ENSG00000092969	ENSG00000106991
Uniprot IDs		P61812	B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0
PDB IDs		1TFG 2TGI
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Epithelial To Mesenchymal Transition Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Organ Morphogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Skeletal System Development Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Anatomical Structure Morphogenesis Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Regulation Of Cartilage Development Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Phosphorus Metabolic Process Bone Development Response To Wounding Regulation Of Signal Transduction Regulation Of Collagen Metabolic Process Regulation Of Cell Differentiation Regulation Of Protein Metabolic Process Skeletal System Morphogenesis Response To Lipid Response To Hypoxia Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Cell Growth Aging	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Ossification Positive Regulation Of Protein Phosphorylation Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Mesenchymal Cell Development Positive Regulation Of Phosphorylation Mesenchymal Cell Differentiation Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Organ Morphogenesis Response To Growth Factor Regulation Of Bone Mineralization Regulation Of Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Proliferation Embryo Development Regulation Of Ossification Cellular Response To Organic Substance Mesenchyme Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Stem Cell Development Response To Lipid Growth Positive Regulation Of Cell Differentiation Gland Development Response To Organic Cyclic Compound Regulation Of Phosphorus Metabolic Process Anatomical Structure Morphogenesis Skeletal System Development Stem Cell Differentiation Sensory Organ Development Response To Organic Substance Tissue Development Tissue Morphogenesis Regulation Of Signal Transduction
Tagcloud ?		beta2 betageo cko conditional congenital crossing die dietz dysregulation eiiacre fetuses flox flper galactosidase genesis harboring lacz loeys multifunctional neuromuscular ocular organs osteoarthritis perinatal perinatally precluding resembled tagged	actualization beach biogenic cable cardio collapse craniocorpography ekg electrolytes ending fainting flunarizin holter hypokinesia orthostatic overstrain psychic psycho saved saving sibellium sickness spo ssep telemetric thirst wreck wreckers zpo
Tagcloud (Difference) ?		beta2 betageo cko conditional congenital crossing die dietz dysregulation eiiacre fetuses flox flper galactosidase genesis harboring lacz loeys multifunctional neuromuscular ocular organs osteoarthritis perinatal perinatally precluding resembled tagged	actualization beach biogenic cable cardio collapse craniocorpography ekg electrolytes ending fainting flunarizin holter hypokinesia orthostatic overstrain psychic psycho saved saving sibellium sickness spo ssep telemetric thirst wreck wreckers zpo
Tagcloud (Intersection) ?