BUB1B and CENPE

Number of citations of the paper that reports this interaction (PubMedID 9763420)
68

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		BUB1B	CENPE
Description		BUB1 mitotic checkpoint serine/threonine kinase B	centromere protein E
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Checkpoint Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Nucleus Chromosome Cytoplasm Spindle Kinetochore Microtubule Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Membrane Midbody Intercellular Bridge Spindle Midzone Mitotic Spindle Mitotic Spindle Midzone
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Kinetochore Binding
	Biological Process	Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Sister Chromatid Segregation Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region	Mitotic Cell Cycle Nuclear Division Microtubule-based Movement Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Chromosome Alignment Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Kinase Activity Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Membraneless Organelle Assembly
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins
Drugs			GSK-923295
Diseases
GWAS		Chronic lymphocytic leukemia ( 24292274 28165464)	Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Schizophrenia ( 28991256) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Testicular germ cell tumor ( 23666240 25877299 28604728 28604732)
Interacting Genes		31 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DHX8 DNMBP FBXO7 HDAC1 HOPX KNL1 MAP3K4 PELI1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RIPK3 SNCG TP73 TRIP13	13 interacting genes: BUB1B CENPF CLK1 CUL1 DNAJB1 DUX1 FANCA NUF2 SEPTIN7 SKP1 TRAF4 UBC USP7
Entrez ID		701	1062
HPRD ID		04176	00316
Ensembl ID		ENSG00000156970	ENSG00000138778
Uniprot IDs		O60566	Q02224
PDB IDs		2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ	1T5C 5JVP 6M4I 8HFH 8OWI 8WHL
Enriched GO Terms of Interacting Partners?		Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Protein Phosphatase Type 2A Complex Protein Phosphatase Activator Activity Cytosol Regulation Of Mitotic Nuclear Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Clathrin Adaptor Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Phosphatase Regulator Activity Regulation Of Cell Cycle Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Membrane Coat Mitotic Spindle Assembly Checkpoint Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome, Centromeric Region Negative Regulation Of Mitotic Nuclear Division Regulation Of Reproductive Process Cell Division Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Chromosome Organization Chromosome Spindle Positive Regulation Of Mitotic Metaphase/anaphase Transition Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Cycle Process Protein Catabolic Process Kinetochore Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Chromosome Organization Centrosome Mitotic Checkpoint Complex Proteolysis Involved In Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Outer Kinetochore Negative Regulation Of Mitotic Nuclear Division Chromosome, Centromeric Region Kinetochore Regulation Of Mitotic Sister Chromatid Separation TORC1 Signaling Ubiquitin Ligase Complex Scaffold Activity Nucleus Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Regulation Of Chromosome Organization Cytosol TOR Signaling Regulation Of Mitotic Metaphase/anaphase Transition Autophagosome Assembly Regulation Of TORC1 Signaling Autophagosome Organization Regulation Of Sister Chromatid Segregation Kinetochore Organization Negative Regulation Of Autophagy Regulation Of Mitotic Nuclear Division Positive Regulation Of Epithelial Cell Apoptotic Process Chromosome Regulation Of Chromosome Segregation Organelle Assembly Regulation Of Nuclear Division Regulation Of TOR Signaling Organelle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Vacuole Organization Cell Division Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Spindle Regulation Of Epithelial Cell Apoptotic Process Protein Monoubiquitination Modification-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Nucleoplasm SCF Ubiquitin Ligase Complex Protein Ubiquitination Negative Regulation Of Cell Cycle Process Negative Regulation Of TORC1 Signaling Regulation Of Embryonic Cell Shape Ubiquitin Protein Ligase Binding Intracellular Signal Transduction Regulation Of Organelle Organization
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