BUB1B and HOPX

Number of citations of the paper that reports this interaction (PubMedID 23345399)
0

Data Source:
BioGRID (two hybrid)

		BUB1B	HOPX
Description		BUB1 mitotic checkpoint serine/threonine kinase B	HOP homeobox
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Checkpoint Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm	Chromatin Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	DNA Binding Protein Binding Histone Deacetylase Regulator Activity
	Biological Process	Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Sister Chromatid Segregation Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region	Negative Regulation Of Transcription By RNA Polymerase II Trophectodermal Cell Differentiation Bundle Of His Development Regulation Of Transcription By RNA Polymerase II Heart Development Regulation Of Heart Contraction Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Negative Regulation Of Cell Differentiation Lung Alveolus Development Chaperone-mediated Protein Complex Assembly Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Gap Junction Assembly
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 24292274 28165464)	Cadmium levels ( 26025379) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systemic sclerosis ( 30247649)
Interacting Genes		31 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DHX8 DNMBP FBXO7 HDAC1 HOPX KNL1 MAP3K4 PELI1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RIPK3 SNCG TP73 TRIP13	10 interacting genes: BUB1B EPC1 HDAC2 HOXB9 PICK1 PTGER4 SRF TCF12 TLX3 ZSCAN1
Entrez ID		701	84525
HPRD ID		04176	06280
Ensembl ID		ENSG00000156970	ENSG00000171476
Uniprot IDs		O60566	Q9BPY8
PDB IDs		2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ
Enriched GO Terms of Interacting Partners?		Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Protein Phosphatase Type 2A Complex Protein Phosphatase Activator Activity Cytosol Regulation Of Mitotic Nuclear Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Clathrin Adaptor Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Phosphatase Regulator Activity Regulation Of Cell Cycle Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Membrane Coat Mitotic Spindle Assembly Checkpoint Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome, Centromeric Region Negative Regulation Of Mitotic Nuclear Division Regulation Of Reproductive Process Cell Division Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Chromosome Organization Chromosome Spindle Positive Regulation Of Mitotic Metaphase/anaphase Transition Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Cycle Process Protein Catabolic Process Kinetochore Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Chromosome Organization Centrosome Mitotic Checkpoint Complex Proteolysis Involved In Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Response To Dopamine Chromatin Sequence-specific Double-stranded DNA Binding Response To Oxygen Levels Eyelid Development In Camera-type Eye Long-term Synaptic Depression Response To Catecholamine Animal Organ Development Monoamine Transport Response To Amphetamine DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Synaptic Transmission Response To Cocaine DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Response To Amine Norepinephrine Secretion Catechol O-methyltransferase Activity Cellular Response To Nutrient Levels Response To Alcohol Response To Hormone Developmental Process Positive Regulation Of Male Mating Behavior Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Negative Regulation Of Eosinophil Extravasation Serum Response Element Binding Cellular Developmental Process Negative Regulation Of Cellular Component Organization Response To Decreased Oxygen Levels Cellular Response To Phosphate Starvation Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Protein De-2-hydroxyisobutyrylase Activity Regulation Of RNA Biosynthetic Process Negative Regulation Of Eosinophil Migration Bronchus Cartilage Development Cis-regulatory Region Sequence-specific DNA Binding Lung Smooth Muscle Development Negative Regulation Of Locomotion Response To Alkaloid Mitotic Checkpoint Complex Meiotic Sister Chromatid Cohesion, Centromeric Habituation Mastication Renal Sodium Excretion Renal Albumin Absorption Renin Secretion Into Blood Stream
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