BUB1B and PELI1

Number of citations of the paper that reports this interaction (PubMedID 28410192)
40

Data Source:
BioGRID (enzymatic study)

		BUB1B	PELI1
Description		BUB1 mitotic checkpoint serine/threonine kinase B	pellino E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Checkpoint Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm	Nucleus Chromosome Cytoplasm Cytosol Site Of Double-strand Break
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Sister Chromatid Segregation Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Cytokine Production DNA Repair DNA Damage Response Regulation Of Toll Signaling Pathway Protein Ubiquitination Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TORC1 Signaling T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To DsRNA Negative Regulation Of T Cell Activation Positive Regulation Of B Cell Activation Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Regulation of necroptotic cell death Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 24292274 28165464)	Allergic dermatitis (nickel) ( 23921680) HOMA-B (corrected for HOMA-IR) ( 30369944) Kawasaki disease ( 21221998)
Interacting Genes		31 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DHX8 DNMBP FBXO7 HDAC1 HOPX KNL1 MAP3K4 PELI1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RIPK3 SNCG TP73 TRIP13	33 interacting genes: BCL6 BIRC3 BUB1B CLEC17A CNTROB EGFR GOSR2 IKBKB INPP5J IRAK1 IRAK2 IRAK4 IRS1 LCN2 LMNA MDM4 RIMS4 RIPK3 SQSTM1 SRPK1 SRPK2 TP53 TP63 TRIP13 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2V1 VAC14 ZAP70
Entrez ID		701	57162
HPRD ID		04176	17834
Ensembl ID		ENSG00000156970	ENSG00000197329
Uniprot IDs		O60566	Q53T26 Q96FA3
PDB IDs		2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ	9IF9
Enriched GO Terms of Interacting Partners?		Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Protein Phosphatase Type 2A Complex Protein Phosphatase Activator Activity Cytosol Regulation Of Mitotic Nuclear Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Clathrin Adaptor Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Phosphatase Regulator Activity Regulation Of Cell Cycle Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Membrane Coat Mitotic Spindle Assembly Checkpoint Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome, Centromeric Region Negative Regulation Of Mitotic Nuclear Division Regulation Of Reproductive Process Cell Division Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Chromosome Organization Chromosome Spindle Positive Regulation Of Mitotic Metaphase/anaphase Transition Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Cycle Process Protein Catabolic Process Kinetochore Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Chromosome Organization Centrosome Mitotic Checkpoint Complex Proteolysis Involved In Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Intracellular Signal Transduction ATP Binding Non-canonical NF-kappaB Signal Transduction Ubiquitin Conjugating Enzyme Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification Process Regulation Of Intracellular Signal Transduction Nucleotide Binding Protein Kinase Activity MyD88-dependent Toll-like Receptor Signaling Pathway Cytosol Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Transferase Activity Interleukin-1-mediated Signaling Pathway Toll Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Protein Polyubiquitination Immune Response-regulating Cell Surface Receptor Signaling Pathway Endosome Membrane Protein-containing Complex Toll-like Receptor 4 Signaling Pathway Protein Ubiquitination Cell Surface Toll-like Receptor Signaling Pathway Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Toll-like Receptor Signaling Pathway Post-translational Protein Modification Response To Stress Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Protein Serine Kinase Activity Immune Response-activating Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Polyubiquitination Cellular Response To Hypoxia Nucleus
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