BUB1B and CASC5

Number of citations of the paper that reports this interaction (PMID 20220147)
13

Data Source:
BioGRID (two hybrid)

		BUB1B	CASC5
Gene Name		BUB1 mitotic checkpoint serine/threonine kinase B	cancer susceptibility candidate 5
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Chromosome Outer Kinetochore Anaphase-promoting Complex Cytoplasm Microtubule Organizing Center Cytosol Perinuclear Region Of Cytoplasm Spindle Midzone	Condensed Chromosome Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Mitotic Nuclear Division Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Kinetochore Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle	Mitotic Cell Cycle Acrosome Assembly Nucleosome Assembly Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Phosphatase Activity CENP-A Containing Nucleosome Assembly Protein Localization To Kinetochore Cell Division Spindle Assembly Checkpoint
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components M Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cell Cycle Checkpoints Mitotic Metaphase and Anaphase	Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB1 BUB3 CASC5 CDC16 CDC20 CDC27 CENPE COMMD4 DNMBP FZR1 HDAC1 MAP3K4 SNCG TP73	6 interactors: BUB1 BUB1B DSN1 MIS12 PPP1CA TTK
Entrez ID		701	57082
HPRD ID		04176	10634
Ensembl ID		ENSG00000156970	ENSG00000137812
Uniprot IDs		O60566	Q8NG31
PDB IDs		2WVI 3SI5 4GGD	3SI5 4A1G
Enriched GO Terms of Interacting Partners?		Spindle Assembly Checkpoint Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Cell Cycle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Cell Division Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Cell Division Mitotic Nuclear Division Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Segregation Negative Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of Chromosome Organization Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Cell Cycle Cell Cycle Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Proteolysis Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity	Cell Division Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Chromosome Segregation Mitotic Cell Cycle Process Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Mitotic Nuclear Division Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Cell Cycle Process Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Cell Division Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Catabolic Process Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process Organelle Organization Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Glycogen Catabolic Process Protein Localization To Kinetochore
Tagcloud ?		accompanying bubr1 deacetylation deficient diffuse distributed dot1 dot1l germinal gv h3k79 histones immunofluorescence incomplete lys79 lysine mad3 mammal meiosis metaphase methylated methyltransferase methyltransferases mouse oocytes qpcr sirna supposed vesicle	13ra2 a12 antigen antigens bage chemo contributing ct ctage1 ddx43 gbm glioblastoma glioma gp100 ihc immunotherapy impressively institute inversely mage mgmt multiforme neoplasia primers rembrandt repository tdrd1 testis verified
Tagcloud (Difference) ?		accompanying bubr1 deacetylation deficient diffuse distributed dot1 dot1l germinal gv h3k79 histones immunofluorescence incomplete lys79 lysine mad3 mammal meiosis metaphase methylated methyltransferase methyltransferases mouse oocytes qpcr sirna supposed vesicle	13ra2 a12 antigen antigens bage chemo contributing ct ctage1 ddx43 gbm glioblastoma glioma gp100 ihc immunotherapy impressively institute inversely mage mgmt multiforme neoplasia primers rembrandt repository tdrd1 testis verified
Tagcloud (Intersection) ?