BUB1B and AP4B1

Number of citations of the paper that reports this interaction (PubMedID 12419313)
0

Data Source:
HPRD (two hybrid)

		BUB1B	AP4B1
Description		BUB1 mitotic checkpoint serine/threonine kinase B	adaptor related protein complex 4 subunit beta 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Checkpoint Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm	Golgi Apparatus Trans-Golgi Network Cytosol Membrane Membrane Coat AP-4 Adaptor Complex Clathrin Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane Cytoplasmic Side Of Trans-Golgi Network Transport Vesicle Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Clathrin Binding
	Biological Process	Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Sister Chromatid Segregation Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region	Protein Targeting Intracellular Protein Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Protein Localization To Somatodendritic Compartment
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases			Cerebral palsy
GWAS		Chronic lymphocytic leukemia ( 24292274 28165464)	Alopecia areata ( 25608926) Breast cancer ( 23535729) Crohn's disease ( 28067908) Mean corpuscular volume ( 32888494) Obesity-related traits ( 23251661) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		31 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DHX8 DNMBP FBXO7 HDAC1 HOPX KNL1 MAP3K4 PELI1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RIPK3 SNCG TP73 TRIP13	4 interacting genes: AP4E1 BUB1 BUB1B ZNF576
Entrez ID		701	10717
HPRD ID		04176	06259
Ensembl ID		ENSG00000156970	ENSG00000134262
Uniprot IDs		O60566	A0AAQ5BGI8 B1ALD1 B1ALD3 B3KSJ4 B4DTG3 Q9Y6B7
PDB IDs		2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ	2MJ7
Enriched GO Terms of Interacting Partners?		Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Protein Phosphatase Type 2A Complex Protein Phosphatase Activator Activity Cytosol Regulation Of Mitotic Nuclear Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Clathrin Adaptor Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Phosphatase Regulator Activity Regulation Of Cell Cycle Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Membrane Coat Mitotic Spindle Assembly Checkpoint Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome, Centromeric Region Negative Regulation Of Mitotic Nuclear Division Regulation Of Reproductive Process Cell Division Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Chromosome Organization Chromosome Spindle Positive Regulation Of Mitotic Metaphase/anaphase Transition Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Cycle Process Protein Catabolic Process Kinetochore Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Chromosome Organization Centrosome Mitotic Checkpoint Complex Proteolysis Involved In Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Meiotic Sister Chromatid Cohesion, Centromeric Meiotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Outer Kinetochore Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Cohesion Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Regulation Of Nuclear Division Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Kinetochore Mitotic Checkpoint Complex Kidney Development AP-4 Adaptor Complex Cargo Adaptor Activity Regulation Of Centromeric Sister Chromatid Cohesion Positive Regulation Of Sarcomere Organization Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Receptor Serine/threonine Kinase Binding Negative Regulation Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Atrial Cardiac Muscle Tissue Morphogenesis Telethonin Binding Negative Regulation Of Cell Cycle Phase Transition Metaphase/anaphase Transition Of Cell Cycle Regulation Of Sarcomere Organization Regulation Of Chromosome Organization Positive Regulation Of Sister Chromatid Cohesion Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cell Cycle Process Adult Heart Development Heart Trabecula Formation Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Regulation Of Organelle Organization Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Regulation Of Sister Chromatid Cohesion Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
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