BUB1B and COMMD4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BUB1B	COMMD4
Description		BUB1 mitotic checkpoint serine/threonine kinase B	COMM domain containing 4
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Checkpoint Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Sister Chromatid Segregation Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region	Signal Transduction
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Neddylation
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 24292274 28165464)	Microalbuminuria ( 31511532) Serum uric acid levels ( 30993211) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		31 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DHX8 DNMBP FBXO7 HDAC1 HOPX KNL1 MAP3K4 PELI1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RIPK3 SNCG TP73 TRIP13	4 interacting genes: BUB1B COMMD1 H2AC4 TBCD
Entrez ID		701	54939
HPRD ID		04176	13083
Ensembl ID		ENSG00000156970	ENSG00000140365
Uniprot IDs		O60566	A0A0B4J287 H3BQF2 Q9H0A8
PDB IDs		2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ	8F2R 8F2U 8P0W
Enriched GO Terms of Interacting Partners?		Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Protein Phosphatase Type 2A Complex Protein Phosphatase Activator Activity Cytosol Regulation Of Mitotic Nuclear Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Clathrin Adaptor Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Phosphatase Regulator Activity Regulation Of Cell Cycle Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Membrane Coat Mitotic Spindle Assembly Checkpoint Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome, Centromeric Region Negative Regulation Of Mitotic Nuclear Division Regulation Of Reproductive Process Cell Division Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Chromosome Organization Chromosome Spindle Positive Regulation Of Mitotic Metaphase/anaphase Transition Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Cycle Process Protein Catabolic Process Kinetochore Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Chromosome Organization Centrosome Mitotic Checkpoint Complex Proteolysis Involved In Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromosome Positive Regulation Of Cholesterol Import Mitotic Checkpoint Complex Meiotic Sister Chromatid Cohesion, Centromeric Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Endosome To Plasma Membrane Protein Transport Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Cholesterol Import Metaphase/anaphase Transition Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle Post-chaperonin Tubulin Folding Pathway Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Tubulin Complex Assembly Plasma Membrane To Endosome Transport Negative Regulation Of Sodium Ion Transmembrane Transport Meiotic Sister Chromatid Cohesion Negative Regulation Of Protein Localization To Cell Surface Adherens Junction Assembly Negative Regulation Of Microtubule Polymerization Negative Regulation Of Sodium Ion Transport Negative Regulation Of Cellular Response To Hypoxia Low-density Lipoprotein Particle Clearance Intracellular Protein Localization Outer Kinetochore CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Regulation Of Endocytic Recycling Cul2-RING Ubiquitin Ligase Complex Copper Ion Homeostasis Positive Regulation Of Protein Localization To Cell Surface Anaphase-promoting Complex Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cellular Response To Hypoxia Protein Localization To Organelle Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Centrosome Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Protein Localization To Cell Surface Phosphatidic Acid Binding Plasma Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Transport Negative Regulation Of Cellular Component Organization Negative Regulation Of Mitotic Nuclear Division Chromosome Beta-tubulin Binding Regulation Of Sodium Ion Transmembrane Transport
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