BUB1B and CDC20

Number of citations of the paper that reports this interaction (PMID 11535616)
196

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		BUB1B	CDC20
Gene Name		BUB1 mitotic checkpoint serine/threonine kinase B	cell division cycle 20
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Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Chromosome Outer Kinetochore Anaphase-promoting Complex Cytoplasm Microtubule Organizing Center Cytosol Perinuclear Region Of Cytoplasm Spindle Midzone	Spindle Pole Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding Protein C-terminus Binding Enzyme Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Mitotic Nuclear Division Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Kinetochore Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle	Mitotic Cell Cycle Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Positive Regulation Of Cell Proliferation Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiosis Regulation Of Dendrite Development Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Positive Regulation Of Synapse Maturation
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components M Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cell Cycle Checkpoints Mitotic Metaphase and Anaphase	Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Phosphorylation of Emi1 Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB1 BUB3 CASC5 CDC16 CDC20 CDC27 CENPE COMMD4 DNMBP FZR1 HDAC1 MAP3K4 SNCG TP73	37 interactors: ANAPC1 ANAPC10 ANAPC2 ANAPC5 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CCNB1 CDC16 CDC27 CDC6 CDR2 CDT1 FBXO5 FZR1 HDAC1 HDAC2 HSF1 HSF2 MAD2L1 MAD2L2 PIM1 PLK1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TCP1 TGFBR1 TK1 UBE2C UBE2S
Entrez ID		701	991
HPRD ID		04176	04686
Ensembl ID		ENSG00000156970	ENSG00000117399
Uniprot IDs		O60566	Q12834
PDB IDs		2WVI 3SI5 4GGD	4GGA 4GGC 4GGD
Enriched GO Terms of Interacting Partners?		Spindle Assembly Checkpoint Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Cell Cycle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Cell Division Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Cell Division Mitotic Nuclear Division Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Segregation Negative Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of Chromosome Organization Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Cell Cycle Cell Cycle Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Proteolysis Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity	Regulation Of Cell Cycle Mitotic Nuclear Division Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Segregation Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Process Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Regulation Of Protein Ubiquitination Negative Regulation Of Chromosome Segregation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Division Negative Regulation Of Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Cell Cycle Cell Cycle Checkpoint Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ligase Activity Negative Regulation Of Chromosome Organization Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Tagcloud ?		accompanying bubr1 deacetylation deficient diffuse distributed dot1 dot1l germinal gv h3k79 histones immunofluorescence incomplete lys79 lysine mad3 mammal meiosis metaphase methylated methyltransferase methyltransferases mouse oocytes qpcr sirna supposed vesicle	abrogates anaphase apc assembles attached bub3 bubr1 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Difference) ?		accompanying deacetylation deficient diffuse distributed dot1 dot1l germinal gv h3k79 histones immunofluorescence incomplete lys79 lysine mad3 mammal meiosis metaphase methylated methyltransferase methyltransferases mouse oocytes qpcr sirna supposed vesicle	abrogates anaphase apc assembles attached bub3 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Intersection) ?		bubr1