TCP10L3 and PARD6A

Number of citations: 0 (PubMedID 10934474)
Data Source: HPRD (two hybrid)

		TCP10L3	PARD6A
Name		t-complex 10 like 3 (pseudogene)	par-6 family cell polarity regulator alpha
Structure		No pdb structure
GO Annotations	Cellular Component	None	Ruffle Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Centriolar Satellite Cell Projection Tight Junction Anchoring Junction PAR Polarity Complex
	Molecular Function	None	Protein Binding GTP-dependent Protein Binding Small GTPase Binding
	Biological Process	None	Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Viral Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Regulation Of Cellular Localization Positive Regulation Of Protein Localization To Centrosome
Pathways		None	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle RHOV GTPase cycle
GWAS		No GWAS studies recorded	Obesity-related traits ( 23251661 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 )
Novel Interactors		1 novel interactors: CEP43	1 novel interactors: ATP5MG
Interacting Genes		5 interacting genes: APP FBXO7 PARD6A PARD6B UBC	27 interacting genes: APP CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ PTPN21 RAC1 RHOQ SNCA TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ
Entrez ID		6953	50855
HPRD ID		01752	06316
Ensembl ID		ENSG00000290751	ENSG00000102981
Uniprot IDs		Not available	Q9NPB6
PDB IDs		Not available	1WMH
GO Terms Enriched among Interactors		PAR Polarity Complex Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Locomotion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Junction Organization Microtubule-based Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Establishment Or Maintenance Of Apical/basal Cell Polarity Centrosome Cycle Microtubule Organizing Center Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Tight Junction Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Cytosol Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Lewy Body Core Bicellular Tight Junction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Axonogenesis Low-density Lipoprotein Particle Mediated Signaling Establishment Or Maintenance Of Cell Polarity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Protein-containing Complex Growth Factor Receptor Binding Main Axon Cell-cell Junction Organization Cell Cortex Regulation Of Spontaneous Synaptic Transmission	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Intracellular Signal Transduction Regulation Of Cellular Component Organization Bicellular Tight Junction PAR Polarity Complex Positive Regulation Of Cellular Component Organization Establishment Of Cell Polarity Cell-cell Junction Organization Diacylglycerol-dependent Serine/threonine Kinase Activity Cell Junction Organization Cell-cell Junction Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity Apical Part Of Cell Signal Transduction Positive Regulation Of Protein Localization Cell Cortex Tight Junction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Synaptic Plasticity Regulation Of Protein Localization Protein Kinase Activity Regulation Of Developmental Process Protein Phosphorylation Positive Regulation Of Cellular Component Biogenesis Protein Serine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Programmed Cell Death Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Phosphorylation GBD Domain Binding Regulation Of Cell Communication Regulation Of Signaling Anchoring Junction Kinase Activity Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cytoplasm Supramolecular Fiber Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Filopodium Assembly Postsynaptic Cytosol