TCP10 and PARD6A

Number of citations of the paper that reports this interaction (PMID 10934474)
205

Data Source:
HPRD (two hybrid)

		TCP10	PARD6A
Gene Name		t-complex 10	par-6 family cell polarity regulator alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Ruffle Nucleus Cytosol Plasma Membrane Tight Junction Cell Cortex Protein Complex Apical Part Of Cell
	Molecular Function		Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding GTP-dependent Protein Binding
	Biological Process		Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Cell Junction Assembly Cell-cell Junction Organization Cell-cell Junction Maintenance Cell Division Tight Junction Assembly
Pathways			Loss of Function of TGFBR2 in Cancer Cell junction organization TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Tight junction interactions Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Cell-cell junction organization Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Asymmetric localization of PCP proteins PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: APP PARD6A PARD6B UBC	24 interactors: CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ RAC1 RHOQ TCP10 TGFBR1 WDR83 YWHAH YWHAZ
Entrez ID		6953	50855
HPRD ID		01752	06316
Ensembl ID			ENSG00000102981
Uniprot IDs		D1MPS5 Q12799	Q9NPB6
PDB IDs			1WMH
Enriched GO Terms of Interacting Partners?		Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Tight Junction Assembly Apical Junction Assembly Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cell-cell Junction Assembly Notch Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Intracellular Receptor Signaling Pathway Cell Junction Assembly Cell-cell Junction Organization Collateral Sprouting In Absence Of Injury Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Cell-cell Junction Maintenance Regulation Of Mitotic Cell Cycle Viral Protein Processing Cell Division Cellular Component Assembly Regulation Of Cell Cycle Process Axonogenesis Cellular Copper Ion Homeostasis Viral Process Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Notch Receptor Processing Copper Ion Homeostasis Suckling Behavior Virion Assembly Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Neuron Projection Morphogenesis Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Component Maintenance Regulation Of Proteolysis	Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Junction Organization Nervous System Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Communication Tight Junction Assembly Signal Transduction Regulation Of Cell Death Regulation Of Cellular Component Organization System Development Positive Regulation Of Signal Transduction Apical Junction Assembly Positive Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Transport Establishment Or Maintenance Of Cell Polarity Regulation Of Cellular Localization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Cell Junction Assembly Multicellular Organismal Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Programmed Cell Death Response To Growth Factor Generation Of Neurons Wound Healing Anatomical Structure Development Cellular Response To Stimulus Positive Regulation Of Cell Death Cell-cell Junction Assembly Neurogenesis Regulation Of Establishment Of Protein Localization Regulation Of Phosphorylation Response To Wounding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Protein Phosphorylation Developmental Process Regulation Of Protein Localization Regulation Of Kinase Activity Cellular Component Assembly Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation
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