TCP10L3 and CEP43

		TCP10L3	CEP43
Description		t-complex 10 like 3 (pseudogene)	centrosomal protein 43
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cytoskeleton Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function		Protein Binding Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Protein Homodimerization Activity
	Biological Process		Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Population Proliferation Cell Projection Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Microtubule Anchoring
Pathways			Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Signaling by FGFR1 in disease AURKA Activation by TPX2
Drugs
Diseases
GWAS
Interacting Genes		5 interacting genes: APP FBXO7 PARD6A PARD6B UBC	4 interacting genes: NAGK OGT PPP2R1B S100A6
Entrez ID		6953	11116
HPRD ID		01752	10392
Ensembl ID		ENSG00000290751	ENSG00000213066
Uniprot IDs			A0A087WV25 B4DH64 O95684
PDB IDs			2D68
Enriched GO Terms of Interacting Partners?		PAR Polarity Complex Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Locomotion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Junction Organization Microtubule-based Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Establishment Or Maintenance Of Apical/basal Cell Polarity Centrosome Cycle Microtubule Organizing Center Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Tight Junction Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Cytosol Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Lewy Body Core Bicellular Tight Junction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Axonogenesis Low-density Lipoprotein Particle Mediated Signaling Establishment Or Maintenance Of Cell Polarity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Protein-containing Complex Growth Factor Receptor Binding Main Axon Cell-cell Junction Organization Cell Cortex Regulation Of Spontaneous Synaptic Transmission	Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Ribonuclease T2 Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity
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