FAS and ANK3

Number of citations of the paper that reports this interaction (PMID 14694156)
9

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FAS	ANK3
Gene Name		Fas cell surface death receptor	ankyrin 3, node of Ranvier (ankyrin G)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Extracellular Vesicular Exosome	Lysosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Tight Junction Basal Plasma Membrane Cell Surface Intercalated Disc Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Lateral Plasma Membrane Sarcoplasmic Reticulum Z Disc T-tubule Dendrite Neuromuscular Junction Node Of Ranvier Paranode Region Of Axon Sarcolemma Costamere Axon Initial Segment Postsynaptic Membrane
	Molecular Function	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Kinase Binding Identical Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Spectrin Binding Protein Binding, Bridging Ion Channel Binding Cadherin Binding
	Biological Process	Immunoglobulin Production Renal System Process Protein Complex Assembly Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Cell Apoptotic Process Transformed Cell Apoptotic Process Signal Transduction Circadian Rhythm Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Toxic Substance B Cell Mediated Immunity Positive Regulation Of Protein Homooligomerization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Thymic T Cell Selection Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Spleen Development Negative Regulation Of B Cell Activation Protein Homooligomerization Response To Glucocorticoid Cellular Response To Mechanical Stimulus Cellular Response To Lithium Ion Cellular Response To Hyperoxia Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hepatocyte Apoptotic Process Necroptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Mitotic Cytokinesis Plasma Membrane Organization Cytoskeletal Anchoring At Plasma Membrane Signal Transduction Axonogenesis Axon Guidance Neuromuscular Junction Development Positive Regulation Of Gene Expression Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Sodium Ion Transport Magnesium Ion Homeostasis Neuronal Action Potential Positive Regulation Of Homotypic Cell-cell Adhesion Golgi To Plasma Membrane Protein Transport Regulation Of Potassium Ion Transport Establishment Of Protein Localization Positive Regulation Of Membrane Potential Cellular Response To Magnesium Ion Membrane Assembly Protein Localization To Plasma Membrane Maintenance Of Protein Location In Plasma Membrane Protein Targeting To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS		Atrioventricular conduction ( 21041692) Immunoglobulin A ( 20694011) Obesity-related traits ( 23251661)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 22182935 21926972 18711365) Bipolar disorder and major depressive disorder (combined) ( 20351715) Schizophrenia ( 20185149)
Protein-Protein Interactions		48 interactors: ANK3 APAF1 APOA5 ATP6V0B BAG6 BTK C14orf1 CALM1 CASP8 CASP8AP2 CCND3 CD47 CRMP1 DAXX EEF1A1 EGFR EZR FADD FAF1 FAF2 FAIM2 FASLG FBF1 FEM1B FYN GADD45A HIPK3 HNRNPC KRIT1 LCK LRIF1 MBD4 MET PDCD6 PRKCA PTPN13 PTPN6 RAP1A RIPK1 SUMO1 TCAP TMX1 TNFSF13 TRADD TRAF3 UBA7 UBE2I UBQLN1	12 interactors: FADD FAS HOOK1 KCNC1 MAPK6 PIK3R1 SCN1B SCN2A SCNN1B SMAD2 SMAD3 SPTBN4
Entrez ID		355	288
HPRD ID		00609	02715
Ensembl ID		ENSG00000026103	ENSG00000151150
Uniprot IDs		P25445	Q12955 Q8NAK2
PDB IDs		1BZI 1DDF 3EWT 3EZQ 3THM 3TJE
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Catalytic Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Response To Stimulus Positive Regulation Of Catalytic Activity Regulation Of Signaling Regulation Of Metabolic Process Response To Stress Positive Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Protein Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signal Transduction Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Innate Immune Response Regulation Of Proteolysis Positive Regulation Of Macrophage Differentiation Response To Mechanical Stimulus Positive Regulation Of Hydrolase Activity Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Communication Regulation Of Protein Kinase Activity Immune Response	Extrinsic Apoptotic Signaling Pathway Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Neuron Apoptotic Process Transmission Of Nerve Impulse Necroptotic Signaling Pathway Primary MiRNA Processing Neuron Death SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Communication Nodal Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Embryonic Foregut Morphogenesis Positive Regulation Of Endopeptidase Activity Lymphocyte Activation Foregut Morphogenesis Paraxial Mesoderm Development Positive Regulation Of Peptidase Activity Cell Differentiation Regulation Of Cell Differentiation Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organismal Development Pericardium Development Apoptotic Process Leukocyte Activation Anatomical Structure Development Programmed Cell Death Regulation Of Myeloid Cell Differentiation Signal Transduction Involved In Regulation Of Gene Expression Transport Protein Complex Assembly Cell Death Death Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Necroptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Abiotic Stimulus Sodium Ion Transmembrane Transport Regulation Of Cysteine-type Endopeptidase Activity Gene Silencing By MiRNA Membrane Depolarization During Action Potential
Tagcloud ?		activities auto catalytically constitute constitutive constitutively construct constructs deleted ds dsrna egfp fusion green inactive inducible jellyfish pkr possess possessed protected serine stranded substitution sufficient threonine transfection tumorigenic visualize	add adipocytes algorithms backward bd bipolar categorical chi2 contingency doi escitalopram expand lithium meaningful mp ordinal pkc psychiatry publication remove rs10761482 snp stepwise suffer swedish switches tables takes variance
Tagcloud (Difference) ?		activities auto catalytically constitute constitutive constitutively construct constructs deleted ds dsrna egfp fusion green inactive inducible jellyfish pkr possess possessed protected serine stranded substitution sufficient threonine transfection tumorigenic visualize	add adipocytes algorithms backward bd bipolar categorical chi2 contingency doi escitalopram expand lithium meaningful mp ordinal pkc psychiatry publication remove rs10761482 snp stepwise suffer swedish switches tables takes variance
Tagcloud (Intersection) ?