FAS and TNFSF13

Number of citations of the paper that reports this interaction (PMID 10706119)
19

Data Source:
HPRD (in vitro)

		FAS	TNFSF13
Gene Name		Fas cell surface death receptor	tumor necrosis factor (ligand) superfamily, member 13
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Extracellular Vesicular Exosome	Extracellular Space Nucleoplasm Cytoplasm Cytosol External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Kinase Binding Identical Protein Binding	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding
	Biological Process	Immunoglobulin Production Renal System Process Protein Complex Assembly Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Cell Apoptotic Process Transformed Cell Apoptotic Process Signal Transduction Circadian Rhythm Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Toxic Substance B Cell Mediated Immunity Positive Regulation Of Protein Homooligomerization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Thymic T Cell Selection Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Spleen Development Negative Regulation Of B Cell Activation Protein Homooligomerization Response To Glucocorticoid Cellular Response To Mechanical Stimulus Cellular Response To Lithium Ion Cellular Response To Hyperoxia Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hepatocyte Apoptotic Process Necroptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Immunoglobulin Production In Mucosal Tissue Positive Regulation Of Germinal Center Formation Signal Transduction Positive Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Isotype Switching To IgA Isotypes
Pathways		Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway	Regulation of mRNA stability by proteins that bind AU-rich elements HuR stabilizes mRNA
Drugs
Diseases
GWAS		Atrioventricular conduction ( 21041692) Immunoglobulin A ( 20694011) Obesity-related traits ( 23251661)	IgA levels ( 22864923) IgA nephropathy ( 22197929) IgM levels ( 23118916) Non-albumin protein levels ( 22558069)
Protein-Protein Interactions		48 interactors: ANK3 APAF1 APOA5 ATP6V0B BAG6 BTK C14orf1 CALM1 CASP8 CASP8AP2 CCND3 CD47 CRMP1 DAXX EEF1A1 EGFR EZR FADD FAF1 FAF2 FAIM2 FASLG FBF1 FEM1B FYN GADD45A HIPK3 HNRNPC KRIT1 LCK LRIF1 MBD4 MET PDCD6 PRKCA PTPN13 PTPN6 RAP1A RIPK1 SUMO1 TCAP TMX1 TNFSF13 TRADD TRAF3 UBA7 UBE2I UBQLN1	10 interactors: CAMK1D FAS FURIN SDC2 TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B
Entrez ID		355	8741
HPRD ID		00609	05128
Ensembl ID		ENSG00000026103	ENSG00000161955
Uniprot IDs		P25445	B3KR02 O75888 Q2QBA2
PDB IDs		1BZI 1DDF 3EWT 3EZQ 3THM 3TJE
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Catalytic Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Response To Stimulus Positive Regulation Of Catalytic Activity Regulation Of Signaling Regulation Of Metabolic Process Response To Stress Positive Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Protein Processing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signal Transduction Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Innate Immune Response Regulation Of Proteolysis Positive Regulation Of Macrophage Differentiation Response To Mechanical Stimulus Positive Regulation Of Hydrolase Activity Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Communication Regulation Of Protein Kinase Activity Immune Response	Lymphocyte Homeostasis Leukocyte Homeostasis Signal Transduction Regulation Of Lymphocyte Activation Signaling Negative Regulation Of Lymphocyte Activation Cell Communication Response To Stimulus Regulation Of Cell Activation Negative Regulation Of Leukocyte Activation Cellular Response To Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Immune System Process B Cell Homeostasis Negative Regulation Of B Cell Activation Homeostasis Of Number Of Cells Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Organic Substance Regulation Of B Cell Proliferation Immunoglobulin Production Response To Organic Cyclic Compound Extracellular Matrix Organization Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Extracellular Structure Organization Cellular Response To Mechanical Stimulus Negative Regulation Of Immune System Process Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Odontogenesis Of Dentin-containing Tooth T Cell Costimulation Response To External Stimulus Programmed Cell Death Positive Regulation Of Leukocyte Migration Cell Death Death Cell Surface Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Dendrite Development Nerve Growth Factor Production Motor Neuron Apoptotic Process Response To Steroid Hormone Extrinsic Apoptotic Signaling Pathway Regulation Of Leukocyte Migration Immune System Process Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Response To Tumor Necrosis Factor
Tagcloud ?		activities auto catalytically constitute constitutive constitutively construct constructs deleted ds dsrna egfp fusion green inactive inducible jellyfish pkr possess possessed protected serine stranded substitution sufficient threonine transfection tumorigenic visualize	aid april bcl2 bcl6 biased capabilities capture decisions deregulation discovered dlbcls ebf1 fusions guides igh immunoglobulin irf8 labor lymphomagenic lymphomas methodologies poised powerful prmd1 readily rearrangements translocations uncover viable
Tagcloud (Difference) ?		activities auto catalytically constitute constitutive constitutively construct constructs deleted ds dsrna egfp fusion green inactive inducible jellyfish pkr possess possessed protected serine stranded substitution sufficient threonine transfection tumorigenic visualize	aid april bcl2 bcl6 biased capabilities capture decisions deregulation discovered dlbcls ebf1 fusions guides igh immunoglobulin irf8 labor lymphomagenic lymphomas methodologies poised powerful prmd1 readily rearrangements translocations uncover viable
Tagcloud (Intersection) ?