EFNB3 and AATF

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		EFNB3	AATF
Name		ephrin B3	apoptosis antagonizing transcription factor
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Presynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Small-subunit Processome
	Molecular Function	Virus Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding	RNA Binding Protein Binding Leucine Zipper Domain Binding
	Biological Process	Cell-cell Signaling Nervous System Development Axon Guidance Adult Walking Behavior Axon Choice Point Recognition Cell Differentiation T Cell Costimulation Symbiont Entry Into Host Cell Ephrin Receptor Signaling Pathway Negative Regulation Of Axonogenesis Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission	Cell Adhesion Regulation Of Mitotic Cell Cycle Embryonic Cleavage Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	NRAGE signals death through JNK
GWAS		Alcohol consumption ( 31358974 )	Body mass index ( 26426971 ) Erectile dysfunction ( 30583798 ) Obesity-related traits ( 23251661 ) Thyroid volume in Hashimoto’s thyroiditis ( 32019955 )
Novel Interactors		1 novel interactors: NUP88	5 novel interactors: CCL5 CCL7 MYO1D NOS2 NPTN
Interacting Genes		8 interacting genes: AATF ELOC EPHA4 EPHB3 P2RX7 RELN RHBDL2 YWHAZ	29 interacting genes: ATM ATR AURKA CHEK1 CHEK2 CPD DAPK3 DAZAP2 EFNB3 FBXO7 HIPK2 LDOC1 LZTR1 MAPT MPHOSPH6 MYCBP2 NEDD4L PALS2 PARP1 PAWR PCBD2 POLR2J RB1 RELA SMAD3 SP1 SS18L1 TSG101 ZNF468
Entrez ID		1949	26574
HPRD ID		03804	12236
Ensembl ID		ENSG00000108947	ENSG00000275700
Uniprot IDs		Q15768	A0A7P0TAR0 A0A7P0TBG4 Q9NY61
PDB IDs		4BKF	5W6A 7MQ8 7MQ9
GO Terms Enriched among Interactors		Neuron Recognition Regulation Of Synapse Organization Cell Recognition Transmembrane-ephrin Receptor Activity Ephrin Receptor Activity Axonal Fasciculation Neuron Projection Fasciculation Central Nervous System Projection Neuron Axonogenesis Regulation Of Synapse Maturation Positive Regulation Of Dendrite Morphogenesis Neuron Projection Guidance Axon Guidance Central Nervous System Neuron Axonogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Long-term Synaptic Potentiation Regulation Of Dendritic Spine Morphogenesis Regulation Of Cell Projection Organization Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Nervous System Development Ephrin Receptor Signaling Pathway Regulation Of Dendrite Morphogenesis DH Domain Binding Lysosome Organization Positive Regulation Of Lateral Motor Column Neuron Migration Reelin Complex Spinal Cord Patterning Cell Adhesion Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Projection Organization Neuromuscular Junction Fasciculation Of Motor Neuron Axon Positive Regulation Of Bleb Assembly Synaptic Target Recognition Regulation Of Dendrite Development Regulation Of Neuron Projection Development Regulation Of Nervous System Development Protein Metabolic Process Macromolecule Catabolic Process Neuron Projection Development Dendrite Fasciculation Of Sensory Neuron Axon Cell Projection Organization Phospholipid Transfer To Membrane Positive Regulation Of Gamma-aminobutyric Acid Secretion Lateral Motor Column Neuron Migration Lipoprotein Particle Receptor Binding Positive Regulation Of Cellular Component Organization Protein Tyrosine Kinase Activity Phagolysosome Assembly NAD Transport	Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Replicative Senescence Positive Regulation Of Metabolic Process Response To Gamma Radiation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Organelle Organization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Programmed Cell Death PML Body Chromatin Organization Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Mitotic Nuclear Division Regulation Of Cellular Response To Heat Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Telomerase Catalytic Core Complex Assembly G2/M Transition Of Mitotic Cell Cycle Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Protein Kinase Activity Cell Cycle G2/M Phase Transition Apoptotic Process Protein Homodimerization Activity Positive Regulation Of Cellular Component Organization Regulation Of Protein Stability Regulation Of Protein Catabolic Process Nucleoplasm Programmed Cell Death