EFNB3 and AATF

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EFNB3	AATF
Gene Name		ephrin-B3	apoptosis antagonizing transcription factor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Nucleolus Cytoplasm Golgi Apparatus Centrosome Focal Adhesion
	Molecular Function	Transmembrane-ephrin Receptor Activity Ephrin Receptor Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Leucine Zipper Domain Binding Poly(A) RNA Binding Tau Protein Binding
	Biological Process	Cell-cell Signaling Nervous System Development Axon Guidance Adult Walking Behavior Viral Process Axon Choice Point Recognition Ephrin Receptor Signaling Pathway	Cellular Response To DNA Damage Stimulus Cell Adhesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Superoxide Anion Generation Embryonic Cleavage Ribosome Biogenesis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE NRAGE signals death through JNK p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		7 interactors: AATF EPHA4 EPHB3 P2RX7 RHBDL2 TCEB1 YWHAZ	26 interactors: ATM ATR CHEK1 CHEK2 CPD DAPK3 DAZAP2 EFNB3 HIPK2 LDOC1 LZTR1 MAPT MPHOSPH6 MPP6 NEDD4L NGDN PAWR PCBD2 POLR2J RB1 RELA SMAD3 SP1 SS18L1 TSG101 ZNF468
Entrez ID		1949	26574
HPRD ID		03804	12236
Ensembl ID		ENSG00000108947	ENSG00000108270
Uniprot IDs		Q15768	Q9NY61
PDB IDs		4BKF
Enriched GO Terms of Interacting Partners?		Regulation Of Rac GTPase Activity Axonal Fasciculation Regulation Of Rac Protein Signal Transduction Neuron Recognition Central Nervous System Projection Neuron Axonogenesis Apoptotic Signaling Pathway Central Nervous System Neuron Axonogenesis Cell Adhesion Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Ephrin Receptor Signaling Pathway Central Nervous System Neuron Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cell Recognition Positive Regulation Of Cell Death Phospholipid Transfer To Membrane NAD Transport Fasciculation Of Motor Neuron Axon Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Secretion Fasciculation Of Sensory Neuron Axon Regulation Of Axonogenesis Phosphorylation Positive Regulation Of Cytolysis Negative Regulation Of Axon Regeneration Golgi Reassembly Multicellular Organismal Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Superoxide Anion Generation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Glutamate Secretion Multicellular Organismal Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Histamine Secretion By Mast Cell Central Nervous System Neuron Differentiation Establishment Of Golgi Localization Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Intracellular Transport Apoptotic Process Golgi Inheritance Programmed Cell Death Regulation Of Amyloid Precursor Protein Biosynthetic Process Cellular Response To Stimulus Cell Death Death Cell Morphogenesis Histamine Secretion	Replicative Senescence Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression DNA Damage Induced Protein Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Cell Aging Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated Apoptotic Signaling Pathway RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Biosynthetic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cell Cycle Checkpoint Regulation Of Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Macromolecule Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Apoptotic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Programmed Cell Death Negative Regulation Of Cell Cycle Cell Cycle Process Cell Death Death Regulation Of Mitotic Nuclear Division Response To Abiotic Stimulus Cell Differentiation Regulation Of Cell Proliferation Gene Expression Developmental Process Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		131i anticancer b6 behind destabilization destabilizing egr1 eph epha2 ephb6 ephrin gadd45b lin metaiodobenzylguanidine metformin mibg miz mycn neuregulin nrg1 ntrk1 perp phenformin radiolabeled scintigraphic sel sel1l	accuracy balb behavioral biomarker circadian comprising cooperativity crucial directed encoded exists explore fact forensic governs hence investigation keeping metabolism microrna mortem pmi reasonably rhythm rhythmicity rnome turn unambiguously view
Tagcloud (Difference) ?		131i anticancer b6 behind destabilization destabilizing egr1 eph epha2 ephb6 ephrin gadd45b lin metaiodobenzylguanidine metformin mibg miz mycn neuregulin nrg1 ntrk1 perp phenformin radiolabeled scintigraphic sel sel1l	accuracy balb behavioral biomarker circadian comprising cooperativity crucial directed encoded exists explore fact forensic governs hence investigation keeping metabolism microrna mortem pmi reasonably rhythm rhythmicity rnome turn unambiguously view
Tagcloud (Intersection) ?