EFNB3 and NUP88

Data Source: HiPPIP (Novel)

		EFNB3	NUP88
Name		ephrin B3	nucleoporin 88
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Presynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol
	Molecular Function	Virus Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Cell-cell Signaling Nervous System Development Axon Guidance Adult Walking Behavior Axon Choice Point Recognition Cell Differentiation T Cell Costimulation Symbiont Entry Into Host Cell Ephrin Receptor Signaling Pathway Negative Regulation Of Axonogenesis Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport MRNA Transport
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
GWAS		Alcohol consumption ( 31358974 )	Adult body size ( 32376654 ) Lymphocyte count ( 32888494 ) Mean platelet volume ( 32888494 )
Novel Interactors		1 novel interactors: NUP88	3 novel interactors: DVL2 EFNB3 EOLA1
Interacting Genes		8 interacting genes: AATF ELOC EPHA4 EPHB3 P2RX7 RELN RHBDL2 YWHAZ	5 interacting genes: AGTR1 CD82 NUP214 NUP98 TFIP11
Entrez ID		1949	4927
HPRD ID		03804	03974
Ensembl ID		ENSG00000108947	ENSG00000108559
Uniprot IDs		Q15768	B4DP20 J3KMX1 Q99567
PDB IDs		4BKF	7MNI 7R5J 7R5K
GO Terms Enriched among Interactors		Neuron Recognition Regulation Of Synapse Organization Cell Recognition Transmembrane-ephrin Receptor Activity Ephrin Receptor Activity Axonal Fasciculation Neuron Projection Fasciculation Central Nervous System Projection Neuron Axonogenesis Regulation Of Synapse Maturation Positive Regulation Of Dendrite Morphogenesis Neuron Projection Guidance Axon Guidance Central Nervous System Neuron Axonogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Long-term Synaptic Potentiation Regulation Of Dendritic Spine Morphogenesis Regulation Of Cell Projection Organization Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Nervous System Development Ephrin Receptor Signaling Pathway Regulation Of Dendrite Morphogenesis DH Domain Binding Lysosome Organization Positive Regulation Of Lateral Motor Column Neuron Migration Reelin Complex Spinal Cord Patterning Cell Adhesion Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Projection Organization Neuromuscular Junction Fasciculation Of Motor Neuron Axon Positive Regulation Of Bleb Assembly Synaptic Target Recognition Regulation Of Dendrite Development Regulation Of Neuron Projection Development Regulation Of Nervous System Development Protein Metabolic Process Macromolecule Catabolic Process Neuron Projection Development Dendrite Fasciculation Of Sensory Neuron Axon Cell Projection Organization Phospholipid Transfer To Membrane Positive Regulation Of Gamma-aminobutyric Acid Secretion Lateral Motor Column Neuron Migration Lipoprotein Particle Receptor Binding Positive Regulation Of Cellular Component Organization Protein Tyrosine Kinase Activity Phagolysosome Assembly NAD Transport	Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Angiotensin Type I Receptor Activity Symbiont Entry Into Host Cell Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Convergent Extension Involved In Neural Plate Elongation Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission RNA Export From Nucleus Nuclear Export Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Telomere Tethering At Nuclear Periphery Import Into Nucleus MRNA Transport Protein Import Into Nucleus Nuclear Pore Cytoplasmic Side Of Nuclear Pore Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Biological Process Involved In Interaction With Host Convergent Extension Involved In Organogenesis RNA Transport Nuclear Pore Cytoplasmic Filaments Convergent Extension Involved In Gastrulation Trans-synaptic Signaling By Trans-synaptic Complex Axon Choice Point Recognition Protein Localization To Nucleus Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Protection From Non-homologous End Joining At Telomere Regulation Of Renal Sodium Excretion Positive Regulation Of Neuron Projection Arborization Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Telomere Localization Nuclear Envelope Nucleobase-containing Compound Transport Nuclear Pore Outer Ring Nuclear Pore Complex Assembly Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Trans-synaptic Signaling, Modulating Synaptic Transmission Nuclear Transport Nucleocytoplasmic Transport Nuclear Inclusion Body Nuclear Export Signal Receptor Activity Convergent Extension Nuclear Pore Nuclear Basket Nuclear Pore Organization