EFNB3 and EPHA4

Number of citations of the paper that reports this interaction (PMID 9484836)
11

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		EFNB3	EPHA4
Gene Name		ephrin-B3	EPH receptor A4
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density Cell Junction Filopodium Axon Dendrite Neuromuscular Junction Early Endosome Membrane Dendritic Spine Perikaryon Axon Terminus Axonal Growth Cone Postsynaptic Membrane
	Molecular Function	Transmembrane-ephrin Receptor Activity Ephrin Receptor Binding	Protein Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding PH Domain Binding Identical Protein Binding Ephrin Receptor Binding DH Domain Binding
	Biological Process	Cell-cell Signaling Nervous System Development Axon Guidance Adult Walking Behavior Viral Process Axon Choice Point Recognition Ephrin Receptor Signaling Pathway	Cell Adhesion Axon Guidance Adult Walking Behavior Motor Neuron Axon Guidance Glial Cell Migration Peptidyl-tyrosine Phosphorylation Corticospinal Tract Morphogenesis Regulation Of Rac GTPase Activity Regulation Of Rap GTPase Activity Positive Regulation Of JUN Kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Regulation Of Astrocyte Differentiation Regulation Of Axonogenesis Positive Regulation Of Dendrite Morphogenesis Regulation Of Dendritic Spine Morphogenesis Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity
Pathways		EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS			Brain imaging ( 20100581) Paclitaxel-induced neuropathy ( 23776197)
Protein-Protein Interactions		7 interactors: AATF EPHA4 EPHB3 P2RX7 RHBDL2 TCEB1 YWHAZ	15 interactors: ARHGEF15 EFNA1 EFNA3 EFNA4 EFNA5 EFNB2 EFNB3 FGFR1 FGFR2 FGFR3 FGFR4 FYN IKBKG NGEF SRC
Entrez ID		1949	2043
HPRD ID		03804	03719
Ensembl ID		ENSG00000108947	ENSG00000116106
Uniprot IDs		Q15768	E9PG71 P54764 Q58F15
PDB IDs		4BKF	2LW8 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF
Enriched GO Terms of Interacting Partners?		Regulation Of Rac GTPase Activity Axonal Fasciculation Regulation Of Rac Protein Signal Transduction Neuron Recognition Central Nervous System Projection Neuron Axonogenesis Apoptotic Signaling Pathway Central Nervous System Neuron Axonogenesis Cell Adhesion Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Ephrin Receptor Signaling Pathway Central Nervous System Neuron Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cell Recognition Positive Regulation Of Cell Death Phospholipid Transfer To Membrane NAD Transport Fasciculation Of Motor Neuron Axon Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Secretion Fasciculation Of Sensory Neuron Axon Regulation Of Axonogenesis Phosphorylation Positive Regulation Of Cytolysis Negative Regulation Of Axon Regeneration Golgi Reassembly Multicellular Organismal Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Superoxide Anion Generation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Glutamate Secretion Multicellular Organismal Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Histamine Secretion By Mast Cell Central Nervous System Neuron Differentiation Establishment Of Golgi Localization Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Intracellular Transport Apoptotic Process Golgi Inheritance Programmed Cell Death Regulation Of Amyloid Precursor Protein Biosynthetic Process Cellular Response To Stimulus Cell Death Death Cell Morphogenesis Histamine Secretion	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Enzyme Linked Receptor Protein Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Axon Guidance Neuron Development Peptidyl-tyrosine Phosphorylation Cell Morphogenesis Neuron Differentiation Cell Projection Organization Chemotaxis Generation Of Neurons Neurogenesis Cell Surface Receptor Signaling Pathway Locomotion Anatomical Structure Morphogenesis Cell Development Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Nervous System Development Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction System Development Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To External Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Cell-cell Signaling Response To Fibroblast Growth Factor Peptidyl-amino Acid Modification Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Autophosphorylation Multicellular Organismal Development Anatomical Structure Development Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Phosphorylation
Tagcloud ?		131i anticancer b6 behind destabilization destabilizing egr1 eph epha2 ephb6 ephrin gadd45b lin metaiodobenzylguanidine metformin mibg miz mycn neuregulin nrg1 ntrk1 perp phenformin radiolabeled scintigraphic sel sel1l	abl adaptor aml1 amongst arising betapdgf chimeric coding dimerization elicits ets folding gtpases hetero homo homodimer homophilic module oligomerize oncogenic property reveals sam scaffolding shared sterile tel threonine
Tagcloud (Difference) ?		131i anticancer b6 behind destabilization destabilizing egr1 epha2 ephb6 ephrin gadd45b lin metaiodobenzylguanidine metformin mibg miz mycn neuregulin nrg1 ntrk1 perp phenformin radiolabeled scintigraphic sel sel1l	abl adaptor aml1 amongst arising betapdgf chimeric coding dimerization elicits ets folding gtpases hetero homo homodimer homophilic module oligomerize oncogenic property reveals sam scaffolding shared sterile tel threonine
Tagcloud (Intersection) ?		eph