EFNB3 and P2RX7

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EFNB3	P2RX7
Gene Name		ephrin-B3	purinergic receptor P2X, ligand gated ion channel, 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Integral Component Of Nuclear Inner Membrane Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Neuromuscular Junction Bleb Neuronal Cell Body Terminal Bouton Protein Complex Membrane Raft
	Molecular Function	Transmembrane-ephrin Receptor Activity Ephrin Receptor Binding	Magnesium Ion Binding Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellular ATP-gated Cation Channel Activity Receptor Binding Copper Ion Binding Protein Binding ATP Binding Zinc Ion Binding Protein Homodimerization Activity Scaffold Protein Binding
	Biological Process	Cell-cell Signaling Nervous System Development Axon Guidance Adult Walking Behavior Viral Process Axon Choice Point Recognition Ephrin Receptor Signaling Pathway	Activation Of MAPK Activity Cell Morphogenesis Phagolysosome Assembly Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Sodium Ion Transport Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Phospholipid Transfer To Membrane Cell Volume Homeostasis Membrane Budding Inflammatory Response Mitochondrion Organization Plasma Membrane Organization Cell Surface Receptor Signaling Pathway Response To Mechanical Stimulus Response To Zinc Ion Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Synaptic Vesicle Exocytosis Protein Processing Neuronal Action Potential Sensory Perception Of Pain Cytolysis Positive Regulation Of Bone Mineralization Cellular Response To Extracellular Stimulus Bleb Assembly Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Collagen Metabolic Process Response To ATP Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway T Cell Proliferation Response To Drug T Cell Homeostasis NAD Transport Negative Regulation Of MAPK Cascade Multicellular Organismal Protein Catabolic Process Innate Immune Response Phospholipid Translocation Negative Regulation Of Bone Resorption Positive Regulation Of Cytolysis Ceramide Biosynthetic Process Pore Complex Assembly Skeletal System Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Gram-positive Bacterium Release Of Sequestered Calcium Ion Into Cytosol Protein Oligomerization Positive Regulation Of Cytoskeleton Organization Response To Calcium Ion Response To Electrical Stimulus Regulation Of Killing Of Cells Of Other Organism Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Lymphocyte Apoptotic Process Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cation Transmembrane Transport
Pathways		EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Protein-Protein Interactions		7 interactors: AATF EPHA4 EPHB3 P2RX7 RHBDL2 TCEB1 YWHAZ	9 interactors: ACTB CASK EFNB3 EMP3 KRT31 KRTAP10-8 PANX1 SVIL TM9SF1
Entrez ID		1949	5027
HPRD ID		03804	03977
Ensembl ID		ENSG00000108947	ENSG00000089041
Uniprot IDs		Q15768	Q99572
PDB IDs		4BKF
Enriched GO Terms of Interacting Partners?		Regulation Of Rac GTPase Activity Axonal Fasciculation Regulation Of Rac Protein Signal Transduction Neuron Recognition Central Nervous System Projection Neuron Axonogenesis Apoptotic Signaling Pathway Central Nervous System Neuron Axonogenesis Cell Adhesion Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Ephrin Receptor Signaling Pathway Central Nervous System Neuron Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cell Recognition Positive Regulation Of Cell Death Phospholipid Transfer To Membrane NAD Transport Fasciculation Of Motor Neuron Axon Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Secretion Fasciculation Of Sensory Neuron Axon Regulation Of Axonogenesis Phosphorylation Positive Regulation Of Cytolysis Negative Regulation Of Axon Regeneration Golgi Reassembly Multicellular Organismal Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Superoxide Anion Generation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Glutamate Secretion Multicellular Organismal Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Histamine Secretion By Mast Cell Central Nervous System Neuron Differentiation Establishment Of Golgi Localization Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Intracellular Transport Apoptotic Process Golgi Inheritance Programmed Cell Death Regulation Of Amyloid Precursor Protein Biosynthetic Process Cellular Response To Stimulus Cell Death Death Cell Morphogenesis Histamine Secretion
Tagcloud ?		131i anticancer b6 behind destabilization destabilizing egr1 eph epha2 ephb6 ephrin gadd45b lin metaiodobenzylguanidine metformin mibg miz mycn neuregulin nrg1 ntrk1 perp phenformin radiolabeled scintigraphic sel sel1l	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Difference) ?		131i anticancer b6 behind destabilization destabilizing egr1 eph epha2 ephb6 ephrin gadd45b lin metaiodobenzylguanidine metformin mibg miz mycn neuregulin nrg1 ntrk1 perp phenformin radiolabeled scintigraphic sel sel1l	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Intersection) ?