ARL2 and TBCD

Number of citations: 35 (PubMedID 10831612)
Data Source: HPRD (in vivo, in vitro)

		ARL2	TBCD
Name		ARF like GTPase 2	tubulin folding cofactor D
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Centrosome Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Lateral Plasma Membrane Ciliary Basal Body	Cytoplasm Centrosome Cytoskeleton Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Lateral Plasma Membrane Anchoring Junction
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding	GTPase Activator Activity Protein Binding Beta-tubulin Binding Protein-folding Chaperone Binding
	Biological Process	Regulation Of Glycolytic Process Protein Folding Centrosome Cycle Positive Regulation Of Cell-substrate Adhesion Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of GTPase Activity Maintenance Of Protein Location In Nucleus Bicellular Tight Junction Assembly Regulation Of Aerobic Respiration	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Protein Folding Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Microtubule Polymerization Adherens Junction Assembly Cell Morphogenesis Involved In Neuron Differentiation Bicellular Tight Junction Assembly
Pathways		Post-chaperonin tubulin folding pathway Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane RAS processing	Post-chaperonin tubulin folding pathway
GWAS		No GWAS studies recorded	Blond vs. brown/black hair color ( 30531825 ) Bone mineral accretion in asthma (oral corticosteroid dose interaction) ( 26025128 ) Mean platelet volume ( 32888494 ) Moderate-to-late spontaneous preterm birth ( 31194736 ) Response to cognitive-behavioural therapy in anxiety and major depressive disorders ( 31123309 )
Interacting Genes		7 interacting genes: ARL2BP LHX4 PDE6D TBCD TBL1X TBL1XR1 UNC119	14 interacting genes: ACD APP ARL2 COMMD4 DEXI MTDH MTNR1B POLR2I POT1 SMAD9 TBCE TERF1 TUBB XRCC6
Entrez ID		402	6904
HPRD ID		11869	05227
Ensembl ID		ENSG00000213465	ENSG00000141556
Uniprot IDs		P36404	A0A804HI02 A0A804HIN6 A0A804HJ32 A0A804HJU6 A0A804HLI2 Q9BTW9
PDB IDs		3DOE 3DOF	Not available
GO Terms Enriched among Interactors		Transcription Repressor Complex Histone Deacetylase Complex Positive Regulation Of Peptidyl-tyrosine Phosphorylation Sensory Perception Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Caveolin-mediated Endocytosis Regulation Of Peptidyl-tyrosine Phosphorylation Medial Motor Column Neuron Differentiation	Nuclear Telomere Cap Complex Telomeric DNA Binding Shelterin Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Telomere Maintenance RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of Telomere Maintenance Telomere Assembly Regulation Of Telomere Maintenance Via Telomerase Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Double-stranded Telomeric DNA Binding Telomeric D-loop Disassembly Positive Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Nuclear Envelope Lumen Telomeric Loop Disassembly Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Chromosome Organization Negative Regulation Of DNA Metabolic Process DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Establishment Of Protein Localization Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleolus Positive Regulation Of Organelle Organization Maintenance Of Transcriptional Fidelity During Transcription Elongation By RNA Polymerase II Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly