ARL2 and ARL2BP

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro)

		ARL2	ARL2BP
Name		ARF like GTPase 2	ARF like GTPase 2 binding protein
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Centrosome Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Lateral Plasma Membrane Ciliary Basal Body	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Centrosome Spindle Cytosol Cytoskeleton Cilium Midbody Ciliary Basal Body Cell Projection
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding	Transcription Coactivator Activity Protein Binding GTPase Regulator Activity
	Biological Process	Regulation Of Glycolytic Process Protein Folding Centrosome Cycle Positive Regulation Of Cell-substrate Adhesion Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of GTPase Activity Maintenance Of Protein Location In Nucleus Bicellular Tight Junction Assembly Regulation Of Aerobic Respiration	Signal Transduction Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of DNA-templated Transcription Maintenance Of Protein Location In Nucleus
Pathways		Post-chaperonin tubulin folding pathway Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane RAS processing	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
GWAS		No GWAS studies recorded	Mean corpuscular hemoglobin concentration ( 29403010 )
Novel Interactors		1 novel interactors: POLA2	2 novel interactors: DDX10 FLT1
Interacting Genes		7 interacting genes: ARL2BP LHX4 PDE6D TBCD TBL1X TBL1XR1 UNC119	6 interacting genes: ARL2 ARL3 CAMK2D CFAP20 MPP3 RAC1
Entrez ID		402	23568
HPRD ID		11869	09808
Ensembl ID		ENSG00000213465	ENSG00000102931
Uniprot IDs		P36404	Q9Y2Y0
PDB IDs		3DOE 3DOF	2K9A 3DOE 3DOF
GO Terms Enriched among Interactors		Transcription Repressor Complex Histone Deacetylase Complex Positive Regulation Of Peptidyl-tyrosine Phosphorylation Sensory Perception Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Caveolin-mediated Endocytosis Regulation Of Peptidyl-tyrosine Phosphorylation Medial Motor Column Neuron Differentiation	Nucleotide Binding Regulation Of Microtubule-based Process Regulation Of Microtubule Polymerization GTPase Activity Positive Regulation Of Microtubule Polymerization Ciliary Basal Body GTP Binding Cell Projection Assembly Plasma Membrane Bounded Cell Projection Assembly Regulation Of Neuronal Synaptic Plasticity Placental Growth Factor Receptor Activity Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway GDP Binding Positive Regulation Of Protein Polymerization Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Positive Regulation Of Supramolecular Fiber Organization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell-substrate Adhesion Cytoskeleton Cilium Neuron Development Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of Relaxation Of Cardiac Muscle Regulation Of Protein Localization To Membrane Anterior Head Development Hyaloid Vascular Plexus Regression Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Ovarian Follicle Development Auditory Receptor Cell Morphogenesis Erythrocyte Enucleation Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb Protein Polyglutamylation Cell-cell Junction Organization Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cytoskeleton Organization Protein Localization To Ciliary Membrane Sodium Channel Inhibitor Activity Regulation Of Synaptic Plasticity