PTTG1 and DNAJA1

Number of citations of the paper that reports this interaction (PubMedID 9915854)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PTTG1	DNAJA1
Description		PTTG1 regulator of sister chromatid separation, securin	DnaJ heat shock protein family (Hsp40) member A1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding Molecular Function Activator Activity	G Protein-coupled Receptor Binding ATPase Activator Activity Protein Binding ATP Binding Zinc Ion Binding Hsp70 Protein Binding Tat Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding C3HC4-type RING Finger Domain Binding
	Biological Process	DNA Repair DNA Damage Response Chromosome Segregation Spermatogenesis Homologous Chromosome Segregation Chromosome Organization Cell Division	Protein Folding Response To Unfolded Protein Response To Heat Negative Regulation Of Protein Ubiquitination Protein Refolding Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
GWAS		Dermatomyositis or juvenile dermatomyositis ( 26362759) Insulin-related traits ( 22791750) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 19838195 21408207 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		29 interacting genes: ANAPC1 ANAPC11 ANAPC2 ANAPC4 AURKA CAMK2A CDC20 CDC27 CDC34 CDH1 CDK1 CFTR CRK CUL1 DNAJA1 FZR1 KEAP1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2N UBE4A UBR5 XRCC6 ZFAND5	30 interacting genes: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR CRBN DSCR9 ERG FZR1 HIVEP1 HMGCL HSPA8 HUNK LINC01554 LSM2 NELFCD NUDT3 OGT PAXIP1 PGR PTEN PTTG1 SNCA SUMO2 SUMO4 TM4SF1 TXN UBC
Entrez ID		9232	3301
HPRD ID		04998	04159
Ensembl ID		ENSG00000164611	ENSG00000086061
Uniprot IDs		O95997 Q6IAL9	B7Z5C0 P31689
PDB IDs		7NJ0 7NJ1	2LO1 2M6Y 6E8M 8E2O
Enriched GO Terms of Interacting Partners?		Proteasomal Protein Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Anaphase-promoting Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Protein Ubiquitination Protein Branched Polyubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Meiotic Cell Cycle Macromolecule Catabolic Process Regulation Of Chromosome Segregation Proteolysis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Regulation Of Cell Cycle Process Catabolic Process Cell Division Cytosol Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Protein Metabolic Process Cytoplasm Ubiquitin Protein Ligase Binding Regulation Of Cell Cycle Response To Oxidative Stress Metaphase/anaphase Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Protein-containing Complex Ubiquitin-protein Transferase Activator Activity Regulation Of Cell Cycle Phase Transition Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Proteasomal Protein Catabolic Process Nucleus Cullin-RING Ubiquitin Ligase Complex	Protein Tag Activity Nucleus Enzyme Binding Negative Regulation Of Protein-containing Complex Assembly Anaphase-promoting Complex Binding Protein Modification By Small Protein Conjugation Ubiquitin Ligase Activator Activity
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