PTTG1 and UBE4A

Number of citations of the paper that reports this interaction (PubMedID 15611659)
0

Data Source:
BioGRID (enzymatic study)

		PTTG1	UBE4A
Description		PTTG1 regulator of sister chromatid separation, securin	ubiquitination factor E4A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding Molecular Function Activator Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	DNA Repair DNA Damage Response Chromosome Segregation Spermatogenesis Homologous Chromosome Segregation Chromosome Organization Cell Division	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination ERAD Pathway
Pathways		APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Dermatomyositis or juvenile dermatomyositis ( 26362759) Insulin-related traits ( 22791750) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 19838195 21408207 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)
Interacting Genes		29 interacting genes: ANAPC1 ANAPC11 ANAPC2 ANAPC4 AURKA CAMK2A CDC20 CDC27 CDC34 CDH1 CDK1 CFTR CRK CUL1 DNAJA1 FZR1 KEAP1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2N UBE4A UBR5 XRCC6 ZFAND5	16 interacting genes: CASP6 CLIC6 EPHA2 FILNC1 GZMB IP6K1 MAVS NFE2L1 PTTG1 RSAD2 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP
Entrez ID		9232	9354
HPRD ID		04998	06793
Ensembl ID		ENSG00000164611	ENSG00000110344
Uniprot IDs		O95997 Q6IAL9	Q14139
PDB IDs		7NJ0 7NJ1	1WGM
Enriched GO Terms of Interacting Partners?		Proteasomal Protein Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Anaphase-promoting Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Protein Ubiquitination Protein Branched Polyubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Meiotic Cell Cycle Macromolecule Catabolic Process Regulation Of Chromosome Segregation Proteolysis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Regulation Of Cell Cycle Process Catabolic Process Cell Division Cytosol Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Protein Metabolic Process Cytoplasm Ubiquitin Protein Ligase Binding Regulation Of Cell Cycle Response To Oxidative Stress Metaphase/anaphase Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Protein-containing Complex Ubiquitin-protein Transferase Activator Activity Regulation Of Cell Cycle Phase Transition Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Proteasomal Protein Catabolic Process Nucleus Cullin-RING Ubiquitin Ligase Complex	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Post-translational Protein Modification Ubiquitin-protein Transferase Activity Regulation Of Protein Localization Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process ATP Binding Molecular Function Activator Activity Protein K6-linked Ubiquitination Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Pyroptotic Inflammatory Response Nucleotide Binding Notochord Cell Development Regulation Of Nucleus Organization Delta7-sterol 5(6)-desaturase Activity Protein K11-linked Ubiquitination Flavin Adenine Dinucleotide Catabolic Process D4 Dopamine Receptor Binding Positive Regulation Of IP-10 Production Negative Regulation Of Viral Genome Replication Response To Stress Axial Mesoderm Formation Regulation Of Establishment Of Protein Localization Cytolytic Granule Lumen C-5 Sterol Desaturase Activity Negative Regulation Of BMP Signaling Pathway VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination D3 Dopamine Receptor Binding Regulation Of Peroxisome Organization Negative Regulation Of Lymphangiogenesis Notochord Formation Alcohol Metabolic Process Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Macromolecule Catabolic Process Protein Autoubiquitination Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Inositol 5-diphosphate Pentakisphosphate 5-kinase Activity Diphosphoinositol Tetrakisphosphate Kinase Activity D2 Dopamine Receptor Binding
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