PTTG1 and UBE4A

Number of citations of the paper that reports this interaction (PMID 15611659)
3

Data Source:
BioGRID (enzymatic study)

		PTTG1	UBE4A
Gene Name		pituitary tumor-transforming 1	ubiquitination factor E4A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Ubiquitin Ligase Complex Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding	Protein Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity
	Biological Process	Mitotic Cell Cycle DNA Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Chromosome Segregation Mitotic Nuclear Division Spermatogenesis Negative Regulation Of Endopeptidase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Cell Division	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Insulin-related traits ( 22791750) Systemic lupus erythematosus ( 21408207)	Fat distribution (HIV) ( 21897333)
Protein-Protein Interactions		15 interactors: ANAPC11 AURKA CAMK2A CDC20 CDC27 CDK1 CUL1 DNAJA1 FZR1 PPP2R5A PTTG1IP RPS10 TP53 UBE4A XRCC6	11 interactors: CASP6 EPHA2 GZMB MAVS PTTG1 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP
Entrez ID		9232	9354
HPRD ID		04998	06793
Ensembl ID		ENSG00000164611	ENSG00000110344
Uniprot IDs		O95997 Q6IAL9	Q14139
PDB IDs			1WGM
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Mitotic Cell Cycle Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Catabolic Process Cell Cycle Process Cell Cycle Checkpoint Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Cell Cycle Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Catabolic Process Regulation Of Cell Cycle Process Protein K11-linked Ubiquitination Regulation Of Cell Division	Protein K48-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Polyubiquitination Positive Regulation Of Innate Immune Response Proteolysis Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Protein Catabolic Process Protein Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Cellular Macromolecule Catabolic Process Cellular Response To Stress Apoptotic Process Immune Response-regulating Signaling Pathway Protein K11-linked Ubiquitination Programmed Cell Death Cell Death Death Protein Metabolic Process Positive Regulation Of Immune Response Immune Response Immune System Process Negative Regulation Of Type I Interferon Production Response To Stress Response To Hypoxia Innate Immune Response Cellular Response To DNA Damage Stimulus Regulation Of Immune Response Positive Regulation Of IP-10 Production Notochord Cell Development Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination
Tagcloud ?		coimmunoprecipitation colorectal critically delta126 eliciting emphasizing emvi extramural g245d gi gst hct116 i255f inc indicator interfered m133k outside pbf periodicals poorer pull r273c sfn transferase ubiquitinated uncharacterised v197e wiley	breakpoint causally complementary concordance dimerization disrupts ends facto frame fused hematopoeitic hematopoetic intrinsically investigators karyotype loc100131626 mdss mll reading rearrangement rearrangements shortly subclass tcf12 terminates transcripts transform uncommon unusual
Tagcloud (Difference) ?		coimmunoprecipitation colorectal critically delta126 eliciting emphasizing emvi extramural g245d gi gst hct116 i255f inc indicator interfered m133k outside pbf periodicals poorer pull r273c sfn transferase ubiquitinated uncharacterised v197e wiley	breakpoint causally complementary concordance dimerization disrupts ends facto frame fused hematopoeitic hematopoetic intrinsically investigators karyotype loc100131626 mdss mll reading rearrangement rearrangements shortly subclass tcf12 terminates transcripts transform uncommon unusual
Tagcloud (Intersection) ?