PTTG1 and ANAPC4

Number of citations of the paper that reports this interaction (PubMedID 25859049)
29

Data Source:
BioGRID (pull down)

		PTTG1	ANAPC4
Description		PTTG1 regulator of sister chromatid separation, securin	anaphase promoting complex subunit 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Periphery
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding Molecular Function Activator Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein Phosphatase Binding
	Biological Process	DNA Repair DNA Damage Response Chromosome Segregation Spermatogenesis Homologous Chromosome Segregation Chromosome Organization Cell Division	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Dermatomyositis or juvenile dermatomyositis ( 26362759) Insulin-related traits ( 22791750) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 19838195 21408207 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Body mass index ( 29273807) Body size at age 10 ( 32376654) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Logical memory (immediate recall) in normal cognition ( 29274321) Multisite chronic pain ( 31194737) Waist circumference adjusted for body mass index ( 34021172) Weight ( 20966902)
Interacting Genes		29 interacting genes: ANAPC1 ANAPC11 ANAPC2 ANAPC4 AURKA CAMK2A CDC20 CDC27 CDC34 CDH1 CDK1 CFTR CRK CUL1 DNAJA1 FZR1 KEAP1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2N UBE4A UBR5 XRCC6 ZFAND5	5 interacting genes: CCNA1 MAD2L1BP PTTG1 UBE2I UBE2S
Entrez ID		9232	29945
HPRD ID		04998	09505
Ensembl ID		ENSG00000164611	ENSG00000053900
Uniprot IDs		O95997 Q6IAL9	B3KN47 Q9UJX5
PDB IDs		7NJ0 7NJ1	4UI9 5A31 5BPW 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Proteasomal Protein Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Anaphase-promoting Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Protein Ubiquitination Protein Branched Polyubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Meiotic Cell Cycle Macromolecule Catabolic Process Regulation Of Chromosome Segregation Proteolysis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Regulation Of Cell Cycle Process Catabolic Process Cell Division Cytosol Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Protein Metabolic Process Cytoplasm Ubiquitin Protein Ligase Binding Regulation Of Cell Cycle Response To Oxidative Stress Metaphase/anaphase Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Protein-containing Complex Ubiquitin-protein Transferase Activator Activity Regulation Of Cell Cycle Phase Transition Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Proteasomal Protein Catabolic Process Nucleus Cullin-RING Ubiquitin Ligase Complex	Cell Division SUMO Conjugating Enzyme Activity O-phosphoseryl-tRNA(Sec) Selenium Transferase Activity Conversion Of Seryl-tRNAsec To Selenocys-tRNAsec Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex RING-like Zinc Finger Domain Binding Chromosome Segregation SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding Mitotic Cell Cycle Phase Transition Cyclin A2-CDK2 Complex Cell Cycle Phase Transition Homologous Chromosome Segregation Deactivation Of Mitotic Spindle Assembly Checkpoint Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Positive Regulation Of Ubiquitin Protein Ligase Activity Nucleus Free Ubiquitin Chain Polymerization Selenocysteine Incorporation Positive Regulation Of Mitotic Sister Chromatid Segregation Anaphase-promoting Complex Binding Mitotic Nuclear Membrane Reassembly Protein K29-linked Ubiquitination Transferase Complex Positive Regulation Of Ubiquitin-protein Transferase Activity Meiotic Chromosome Segregation Exit From Mitosis Regulation Of Exit From Mitosis Protein K27-linked Ubiquitination Positive Regulation Of Mitotic Metaphase/anaphase Transition Ubiquitin-like Protein Transferase Activity Transcription Factor Binding SUMO Transferase Activity Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Synaptonemal Complex Nuclear Membrane Reassembly Molecular Function Activator Activity Protein K6-linked Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Male Meiosis I Presynaptic Cytosol Postsynaptic Cytosol Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Chromosome Segregation Male Gamete Generation
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