PTTG1 and CDC20

Number of citations of the paper that reports this interaction (PMID 11553328)
42

Data Source:
HPRD (in vivo, in vitro)

		PTTG1	CDC20
Gene Name		pituitary tumor-transforming 1	cell division cycle 20
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Spindle Pole Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding	Protein Binding Protein C-terminus Binding Enzyme Binding
	Biological Process	Mitotic Cell Cycle DNA Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Chromosome Segregation Mitotic Nuclear Division Spermatogenesis Negative Regulation Of Endopeptidase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Cell Division	Mitotic Cell Cycle Cell Cycle Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Positive Regulation Of Cell Proliferation Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiosis Regulation Of Dendrite Development Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Positive Regulation Of Synapse Maturation
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins	Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Phosphorylation of Emi1 Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS		Insulin-related traits ( 22791750) Systemic lupus erythematosus ( 21408207)
Protein-Protein Interactions		15 interactors: ANAPC11 AURKA CAMK2A CDC20 CDC27 CDK1 CUL1 DNAJA1 FZR1 PPP2R5A PTTG1IP RPS10 TP53 UBE4A XRCC6	37 interactors: ANAPC1 ANAPC10 ANAPC2 ANAPC5 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CCNB1 CDC16 CDC27 CDC6 CDR2 CDT1 FBXO5 FZR1 HDAC1 HDAC2 HSF1 HSF2 MAD2L1 MAD2L2 PIM1 PLK1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TCP1 TGFBR1 TK1 UBE2C UBE2S
Entrez ID		9232	991
HPRD ID		04998	04686
Ensembl ID		ENSG00000164611	ENSG00000117399
Uniprot IDs		O95997 Q6IAL9	Q12834
PDB IDs			4GGA 4GGC 4GGD
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Mitotic Cell Cycle Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Catabolic Process Cell Cycle Process Cell Cycle Checkpoint Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Cell Cycle Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Catabolic Process Regulation Of Cell Cycle Process Protein K11-linked Ubiquitination Regulation Of Cell Division	Regulation Of Cell Cycle Mitotic Nuclear Division Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Segregation Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Process Regulation Of Mitotic Sister Chromatid Separation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Regulation Of Protein Ubiquitination Negative Regulation Of Chromosome Segregation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Division Negative Regulation Of Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Protein Catabolic Process Regulation Of Proteolysis Negative Regulation Of Cell Cycle Cell Cycle Checkpoint Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ligase Activity Negative Regulation Of Chromosome Organization Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Tagcloud ?		coimmunoprecipitation colorectal critically delta126 eliciting emphasizing emvi extramural g245d gi gst hct116 i255f inc indicator interfered m133k outside pbf periodicals poorer pull r273c sfn transferase ubiquitinated uncharacterised v197e wiley	abrogates anaphase apc assembles attached bub3 bubr1 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Difference) ?		coimmunoprecipitation colorectal critically delta126 eliciting emphasizing emvi extramural g245d gi gst hct116 i255f inc indicator interfered m133k outside pbf periodicals poorer pull r273c sfn transferase ubiquitinated uncharacterised v197e wiley	abrogates anaphase apc assembles attached bub3 bubr1 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Intersection) ?