PTTG1 and RPS10

Number of citations of the paper that reports this interaction (PMID 9915854)
3

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		PTTG1	RPS10
Gene Name		pituitary tumor-transforming 1	ribosomal protein S10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Mitotic Cell Cycle DNA Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Chromosome Segregation Mitotic Nuclear Division Spermatogenesis Negative Regulation Of Endopeptidase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Cell Division	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Insulin-related traits ( 22791750) Systemic lupus erythematosus ( 21408207)
Protein-Protein Interactions		15 interactors: ANAPC11 AURKA CAMK2A CDC20 CDC27 CDK1 CUL1 DNAJA1 FZR1 PPP2R5A PTTG1IP RPS10 TP53 UBE4A XRCC6	15 interactors: APP DMPK DNMT3B DVL3 EED FBXO25 HAP1 HIP1 KAT7 PFN2 PTTG1 SYK TCF25 WIZ XRCC6
Entrez ID		9232	6204
HPRD ID		04998	04697
Ensembl ID		ENSG00000164611	ENSG00000124614
Uniprot IDs		O95997 Q6IAL9	P46783
PDB IDs			3J3A
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Mitotic Cell Cycle Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Catabolic Process Cell Cycle Process Cell Cycle Checkpoint Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Cell Cycle Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Catabolic Process Regulation Of Cell Cycle Process Protein K11-linked Ubiquitination Regulation Of Cell Division	Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Chromosome Organization Organelle Organization Gene Expression Regulation Of Vesicle-mediated Transport Positive Regulation Of Organelle Organization Regulation Of Exocytosis Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of Protein Modification Process Genetic Imprinting Regulation Of Cell Differentiation Transcription, DNA-templated Positive Regulation Of Histone Methylation RNA Metabolic Process Regulation Of Gene Expression, Epigenetic Regulation Of Catalytic Activity RNA Biosynthetic Process Positive Regulation Of Cell Cycle Process DNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Axon Cargo Transport Regulation Of Cellular Process Regulation Of Histone Methylation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Positive Regulation Of Cell Cycle Regulation Of Cellular Component Organization Regulation Of Neurogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Platelet Degranulation Positive Regulation Of JUN Kinase Activity Positive Regulation Of Histone Modification
Tagcloud ?		coimmunoprecipitation colorectal critically delta126 eliciting emphasizing emvi extramural g245d gi gst hct116 i255f inc indicator interfered m133k outside pbf periodicals poorer pull r273c sfn transferase ubiquitinated uncharacterised v197e wiley	26t 2a aberrations anemia blackfan cgh congenital copy dba deletions diamond fourfold haploinsufficiency heterozygous hyperactivation hypoproliferative korean malformations predisposition reductions rpl11 rpl35a rpl5 rps17 rps19 rps24 rps26 supports variations
Tagcloud (Difference) ?		coimmunoprecipitation colorectal critically delta126 eliciting emphasizing emvi extramural g245d gi gst hct116 i255f inc indicator interfered m133k outside pbf periodicals poorer pull r273c sfn transferase ubiquitinated uncharacterised v197e wiley	26t 2a aberrations anemia blackfan cgh congenital copy dba deletions diamond fourfold haploinsufficiency heterozygous hyperactivation hypoproliferative korean malformations predisposition reductions rpl11 rpl35a rpl5 rps17 rps19 rps24 rps26 supports variations
Tagcloud (Intersection) ?