HSPA13 and AHCY

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		HSPA13	AHCY
Name		heat shock protein family A (Hsp70) member 13	adenosylhomocysteinase
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Melanosome Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone	Adenosylhomocysteinase Activity Protein Binding Hydrolase Activity
	Biological Process	Protein Folding Protein Refolding	One-carbon Metabolic Process S-adenosylmethionine Cycle
Pathways		Regulation of HSF1-mediated heat shock response	Methylation Sulfur amino acid metabolism Metabolism of ingested SeMet, Sec, MeSec into H2Se Defective AHCY causes HMAHCHD
Drugs		Copper	(1'R,2'S)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-yl)Adenine 3'-Oxo-Adenosine D-Eritadenine Copper
Diseases		None	Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		No GWAS studies recorded	Fish- and plant-related diet ( 32066663 ) Heel bone mineral density ( 30598549 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Vitiligo ( 27723757 ) Walking pace ( 33128006 )
Interacting Genes		43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT	11 interacting genes: APPBP2 C1orf50 CEBPA FXR1 HSPA13 POT1 PXN TERF1 UBC UFL1 YWHAQ
Entrez ID		6782	191
HPRD ID		03061	01621
Ensembl ID		ENSG00000155304	ENSG00000101444
Uniprot IDs		A0A140VK72 P48723	A0A384MTQ3 P23526
PDB IDs		Not available	1A7A 1LI4 3NJ4 4PFJ 4PGF 4YVF 5W49 5W4B
GO Terms Enriched among Interactors		Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process	Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Microtubule Associated Complex Negative Regulation Of Telomere Maintenance RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly UFM1 Ligase Activity Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Response To Vitamin B2 C/EBP Complex Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication UFM1 Transferase Activity Positive Regulation Of Telomeric Loop Disassembly Nucleus Negative Regulation Of Cell Cycle Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process CHOP-C/EBP Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cytoplasmic Stress Granule Positive Regulation Of Reticulophagy 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Inflammatory Response White Fat Cell Proliferation Regulation Of Telomere Maintenance