HSPA13 and LRBA

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		HSPA13	LRBA
Name		heat shock protein family A (Hsp70) member 13	LPS responsive beige-like anchor protein
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone	Protein Binding Protein Kinase Binding
	Biological Process	Protein Folding Protein Refolding	Mitophagy Intracellular Protein Localization Protein Localization To Phagophore Assembly Site
Pathways		Regulation of HSF1-mediated heat shock response	None
Drugs		Copper	None
GWAS		No GWAS studies recorded	Drug-induced hepatocellular liver injury ( 28043905 ) Ear morphology ( 26105758 ) Gallstone disease ( 30504769 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Helix rolling ( 26105758 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Neutrophil count ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Systolic blood pressure ( 30224653 ) White blood cell count ( 32888494 )
Novel Interactors		None recorded	1 novel interactors: TUBGCP3
Interacting Genes		43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT	2 interacting genes: HSPA13 USP7
Entrez ID		6782	987
HPRD ID		03061	07344
Ensembl ID		ENSG00000155304	ENSG00000198589
Uniprot IDs		A0A140VK72 P48723	A0A494BZW2 A0A494C1L5 A0A8V8TKR0 P50851
PDB IDs		Not available	1T77
GO Terms Enriched among Interactors		Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process	Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Polar Microtubule Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Monoubiquitinated Protein Deubiquitination DNA Alkylation Repair Regulation Of Telomere Capping Transcription-coupled Nucleotide-excision Repair Microtubule Minus-end Binding Gamma-tubulin Complex Negative Regulation Of Gluconeogenesis K48-linked Deubiquitinase Activity