HSPA13 and ST18

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		HSPA13	ST18
Name		heat shock protein family A (Hsp70) member 13	ST18 C2H2C-type zinc finger transcription factor
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Chromatin Nucleus Protein-DNA Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Folding Protein Refolding	Regulation Of DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Interleukin-6-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway
Pathways		Regulation of HSF1-mediated heat shock response	None
Drugs		Copper	None
GWAS		No GWAS studies recorded	Age at first sexual intercourse ( 34211149 ) Alzheimer's disease (cognitive decline) ( 23535033 ) Chronotype ( 30696823 ) Frontotemporal dementia (age at onset) ( 29724592 ) Frontotemporal dementia with GRN mutation (age at onset) ( 29724592 ) General risk tolerance (MTAG) ( 30643258 ) Glaucoma (primary angle closure) ( 27064256 ) Morning person ( 30696823 ) Motion sickness ( 25628336 ) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288 ) Psychotic experience (distressing) ( 31553412 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Type 2 diabetes ( 31049640 )
Interacting Genes		43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT	2 interacting genes: HSPA13 PCNT
Entrez ID		6782	9705
HPRD ID		03061	18110
Ensembl ID		ENSG00000155304	ENSG00000147488
Uniprot IDs		A0A140VK72 P48723	O60284
PDB IDs		Not available	2CS8
GO Terms Enriched among Interactors		Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process	None