HSPA13 and PTGES2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HSPA13	PTGES2
Description		heat shock protein family A (Hsp70) member 13	prostaglandin E synthase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Golgi Membrane Extracellular Region Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone	DNA Binding Protein Binding Lyase Activity Isomerase Activity Heme Binding 12-hydroxyheptadecatrienoic Acid Synthase Activity Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	Protein Folding Protein Refolding	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Positive Regulation Of DNA-templated Transcription Prostanoid Biosynthetic Process Secretion
Pathways		Regulation of HSF1-mediated heat shock response	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Neutrophil degranulation
Drugs		Copper
Diseases			Penile cancer
GWAS			Body mass index ( 26426971)
Interacting Genes		43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT	6 interacting genes: ADRB2 CEBPB CFAP141 EXOSC10 HSPA13 PTGFR
Entrez ID		6782	80142
HPRD ID		03061	07458
Ensembl ID		ENSG00000155304	ENSG00000148334
Uniprot IDs		A0A140VK72 P48723	A0A7I2V5X6 A6NHH0 B3KPZ2 B4DWP1 Q9H7Z7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process	Regulation Of Sodium-dependent Phosphate Transport Regulation Of Phosphate Transport Brown Fat Cell Differentiation Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Mini Excitatory Postsynaptic Potential Photoreactive Repair Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Prostaglandin F Receptor Activity Beta2-adrenergic Receptor Activity Granuloma Formation C/EBP Complex Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Positive Regulation Of Cold-induced Thermogenesis T-helper 1 Cell Activation Kinase Binding CHOP-C/EBP Complex Positive Regulation Of Sodium-dependent Phosphate Transport Cry-Per Complex Regulation Of Homologous Chromosome Segregation U5 SnRNA Binding Norepinephrine Binding Negative Regulation Of Glucocorticoid Secretion Sno(s)RNA Catabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Response To Psychosocial Stress Fat Cell Differentiation Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway SnRNA Catabolic Process CUT Catabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Autophagosome Maturation Regulation Of Cold-induced Thermogenesis Heat Generation Nucleic Acid Metabolic Process Hepatocyte Proliferation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Blue Light Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway
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