HSPA13 and UBR4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HSPA13	UBR4
Description		heat shock protein family A (Hsp70) member 13	ubiquitin protein ligase E3 component n-recognin 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Folding Protein Refolding	Cytoplasmic Translation Translational Initiation Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Fatty Acid Biosynthetic Process Response To Oxidative Stress Endosome Organization Proteasomal Protein Catabolic Process Positive Regulation Of Autophagy Protein Ubiquitination Protein Catabolic Process Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K27-linked Ubiquitination Negative Regulation Of Fatty Acid Biosynthetic Process Protein Stabilization Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Targeting To Vacuole Involved In Autophagy Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Cytoplasm Protein Quality Control HRI-mediated Signaling Negative Regulation Of HRI-mediated Signaling Protein Branched Polyubiquitination
Pathways		Regulation of HSF1-mediated heat shock response	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Copper	Verpasep caltespen Picolinic acid
Diseases
GWAS			Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Composite immunoglobulin trait (IgA/IgG) ( 28628107)
Interacting Genes		43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT	18 interacting genes: ACE2 ADRA1A AGTR1 CALM1 ERG HSPA13 MTNR1A MTNR1B MYCN PRPF40A SRGN SRPK2 SUMO2 TTC3 UBC UBE2B UBE2D2 UBE2L3
Entrez ID		6782	23352
HPRD ID		03061	10184
Ensembl ID		ENSG00000155304	ENSG00000127481
Uniprot IDs		A0A140VK72 P48723	Q5T4S7
PDB IDs			8B5W 8BTL 8J9Q 8J9R
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process	Regulation Of Vasoconstriction Regulation Of Blood Circulation Melatonin Receptor Activity Ubiquitin Conjugating Enzyme Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Action Potential Positive Regulation Of Cardiac Muscle Contraction Protein Modification By Small Protein Conjugation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Nucleoplasm Positive Regulation Of Striated Muscle Contraction Regulation Of Cardiac Muscle Contraction Protein Modification Process Proteolysis Protein Tag Activity Ubiquitin-protein Transferase Activity Vascular Process In Circulatory System Regulation Of Striated Muscle Contraction Post-translational Protein Modification Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of System Process Protein Metabolic Process Ubiquitin Protein Ligase Binding Modification-dependent Protein Catabolic Process Circulatory System Process Protein Ubiquitination Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Reactive Oxygen Species Metabolic Process Presynaptic Cytosol G Protein-coupled Receptor Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Muscle Contraction Regulation Of Blood Pressure Positive Regulation Of Heart Contraction Protein K11-linked Ubiquitination G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure Angiotensin Type I Receptor Activity Maintenance Of Granzyme B Location In T Cell Secretory Granule Maintenance Of Protease Location In Mast Cell Secretory Granule T Cell Secretory Granule Organization Regulation Of Heart Contraction Positive Regulation Of Muscle Contraction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine
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