HSPA13 and RMI1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		HSPA13	RMI1
Description		heat shock protein family A (Hsp70) member 13	RecQ mediated genome instability 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Nucleus Nucleoplasm Nuclear Body RecQ Family Helicase-topoisomerase III Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone	Nucleotide Binding Protein Binding
	Biological Process	Protein Folding Protein Refolding	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination Response To Dietary Excess Reduction Of Food Intake In Response To Dietary Excess DNA Replication Response To Glucose Multicellular Organism Growth Glucose Homeostasis Resolution Of DNA Recombination Intermediates
Pathways		Regulation of HSF1-mediated heat shock response	HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs		Copper
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Childhood body mass index ( 33045005) Hip circumference adjusted for BMI ( 34021172) Menarche (age at onset) ( 25231870 27182965) Molar-incisor hypomineralization ( 23918034) Response to statin therapy ( 20339536) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275) Smoking status (ever vs never smokers) ( 30643258) Triglycerides ( 30275531)
Interacting Genes		43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT	5 interacting genes: FANCM HSPA13 NR1H2 PFDN1 UBE3A
Entrez ID		6782	80010
HPRD ID		03061	09867
Ensembl ID		ENSG00000155304	ENSG00000178966
Uniprot IDs		A0A140VK72 P48723	Q9H9A7
PDB IDs			3MXN 3NBH 3NBI 4CGY 4CHT 4DAY 7XUV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process	Regulation Of Protein Metabolic Process Protein Folding Chaperone Positive Regulation Of Post-translational Protein Modification Sperm Entry Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Protein Ubiquitination Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Hormone-mediated Signaling Pathway Regulation Of Golgi Lumen Acidification Regulation Of High-density Lipoprotein Particle Assembly Protein Folding Prefoldin Complex Positive Regulation Of Protein Localization To Lysosome Regulation Of Protein Ubiquitination Positive Regulation Of Cellular PH Reduction Regulation Of Post-translational Protein Modification Intracellular Receptor Signaling Pathway Apolipoprotein A-I Receptor Binding Negative Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Pinocytosis Double-strand Break Repair Via Synthesis-dependent Strand Annealing Four-way Junction Helicase Activity FANCM-MHF Complex Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination Prostate Gland Growth Negative Regulation Of Cholesterol Storage Progesterone Receptor Signaling Pathway Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Digestive System Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Macrophage Derived Foam Cell Differentiation 3'-5' DNA Helicase Activity Fanconi Anaemia Nuclear Complex Negative Regulation Of Amyloid Fibril Formation Phosphatidylcholine Acyl-chain Remodeling ATP Hydrolysis Activity Positive Regulation Of Protein Modification Process Regulation Of Proteolysis Nuclear Retinoid X Receptor Binding Resolution Of Meiotic Recombination Intermediates Four-way Junction DNA Binding Regulation Of Amyloid Fibril Formation Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Protein Localization Androgen Receptor Signaling Pathway
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