HSPA13 and SSR1

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		HSPA13	SSR1
Name		heat shock protein family A (Hsp70) member 13	signal sequence receptor subunit 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone	Protein Binding
	Biological Process	Protein Folding Protein Refolding	Cotranslational Protein Targeting To Membrane Positive Regulation Of Cell Population Proliferation
Pathways		Regulation of HSF1-mediated heat shock response	SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes
Drugs		Copper	None
GWAS		No GWAS studies recorded	Brain morphology (MOSTest) ( 32665545 ) Ewing sarcoma ( 30093639 ) Hip circumference adjusted for BMI ( 34021172 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Subcortical volume (MOSTest) ( 32665545 ) Type 2 diabetes ( 24509480 28869590 30718926 32499647 )
Novel Interactors		None recorded	1 novel interactors: NPC2
Interacting Genes		43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT	8 interacting genes: DKC1 EEF1A1 HSPA13 NUP54 ODC1 PTN SERPINF2 UTP14A
Entrez ID		6782	6745
HPRD ID		03061	02924
Ensembl ID		ENSG00000155304	ENSG00000124783
Uniprot IDs		A0A140VK72 P48723	C9JBX5 P43307
PDB IDs		Not available	8B6L
GO Terms Enriched among Interactors		Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process	None