SSTR2 and SHANK1

Number of citations of the paper that reports this interaction (PubMedID 10551867)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		SSTR2	SHANK1
Description		somatostatin receptor 2	SH3 and multiple ankyrin repeat domains 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Neuron Projection	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Dendrite Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding PDZ Domain Binding Neuropeptide Binding	G Protein-coupled Receptor Binding Protein Binding SH3 Domain Binding Signaling Receptor Complex Adaptor Activity Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Density
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Somatostatin Signaling Pathway Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus	Nervous System Development Long-term Memory Associative Learning Cell Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Cognition Determination Of Affect Righting Reflex Synapse Maturation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior AMPA Selective Glutamate Receptor Signaling Pathway Maintenance Of Postsynaptic Density Structure Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Vapreotide Pasireotide Lanreotide Somatostatin Dotatate gallium Ga-68 Lutetium Lu 177 dotatate Edotreotide gallium Ga-68 Copper oxodotreotide Cu-64
Diseases
GWAS		Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Metabolite levels ( 23823483)	Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)
Interacting Genes		10 interacting genes: APP CORT DRD2 GNA14 GNAI1 PIK3R1 PTPN6 SHANK1 SHANK2 SST	23 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 FXR1 HOMER1 PRMT2 RPS6KA2 RPS6KA3 SHANK3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 TSC1 USP8
Entrez ID		6752	50944
HPRD ID		01674	05413
Ensembl ID		ENSG00000180616	ENSG00000161681
Uniprot IDs		P30874	H9KV90 Q9Y566
PDB IDs		7T10 7T11 7UL5 7WIC 7WIG 7WJ5 7XAT 7XAU 7XAV 7XMR 7Y24 7Y26 7Y27 7YAC 7YAE	6CPI 6YWZ 6YX0 6YX1 6YX2 7A00 8S1R
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Associative Learning Ionotropic Glutamate Receptor Binding Adult Behavior Dendritic Spine Learning Synaptic Receptor Adaptor Activity Regulation Of Biological Quality Synapse Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Learning Or Memory Cognition Chemical Synaptic Transmission Cell Surface Receptor Signaling Pathway Trans-synaptic Signaling Signal Transduction Synaptic Signaling SH3 Domain Binding Memory Guanyl Nucleotide Binding Receptor Ligand Activity Regulation Of Defense Response Regulation Of Neurotransmitter Uptake Insulin Receptor Binding Regulation Of Membrane Potential Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Synaptic Transmission Neuronal Dense Core Vesicle Regulation Of Protein Transport G Protein-coupled Dopamine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Vocalization Behavior Regulation Of Innate Immune Response Cell Activation Involved In Immune Response Synapse Cell Junction Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Migration Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Positive Regulation Of Receptor Internalization Modulation Of Chemical Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Cell Motility Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Establishment Of Protein Localization	Synapse Postsynaptic Density Neuron Projection Regulation Of Cellular Component Organization Neuron Spine Glutamatergic Synapse Signal Transduction Dendritic Spine Latrotoxin Receptor Activity Cell Projection Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Postsynapse AMPA Glutamate Receptor Clustering Neuron Projection Organization Ribosomal Protein S6 Kinase Activity Postsynapse Organization Regulation Of Postsynapse Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Synapse Organization Chemical Synaptic Transmission Learning Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Trans-synaptic Signaling Synaptic Signaling TORC1 Signaling Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Plasma Membrane Scaffold Protein Binding Regulation Of Cell Communication Regulation Of Signaling Endocytic Vesicle Membrane Positive Regulation Of Signal Transduction Neurotransmitter-gated Ion Channel Clustering Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Axon Regulation Of Signal Transduction PDZ Domain Binding Costamere Cytosol TOR Signaling Regulation Of Biological Quality Positive Regulation Of Developmental Process Postsynaptic Membrane
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