SSTR2 and SHANK2

Number of citations of the paper that reports this interaction (PubMedID 10373412)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SSTR2	SHANK2
Description		somatostatin receptor 2	SH3 and multiple ankyrin repeat domains 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Neuron Projection	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane
	Molecular Function	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding PDZ Domain Binding Neuropeptide Binding	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Somatostatin Signaling Pathway Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Vapreotide Pasireotide Lanreotide Somatostatin Dotatate gallium Ga-68 Lutetium Lu 177 dotatate Edotreotide gallium Ga-68 Copper oxodotreotide Cu-64
Diseases
GWAS		Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Metabolite levels ( 23823483)	Bipolar disorder ( 31043756 34002096) Eosinophilic esophagitis ( 34506852) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes		10 interacting genes: APP CORT DRD2 GNA14 GNAI1 PIK3R1 PTPN6 SHANK1 SHANK2 SST	21 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		6752	22941
HPRD ID		01674	04479
Ensembl ID		ENSG00000180616	ENSG00000162105
Uniprot IDs		P30874	A0A590UJ45 A6NHU9 Q9UPX8
PDB IDs		7T10 7T11 7UL5 7WIC 7WIG 7WJ5 7XAT 7XAU 7XAV 7XMR 7Y24 7Y26 7Y27 7YAC 7YAE	8ATJ 8B10
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Associative Learning Ionotropic Glutamate Receptor Binding Adult Behavior Dendritic Spine Learning Synaptic Receptor Adaptor Activity Regulation Of Biological Quality Synapse Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Learning Or Memory Cognition Chemical Synaptic Transmission Cell Surface Receptor Signaling Pathway Trans-synaptic Signaling Signal Transduction Synaptic Signaling SH3 Domain Binding Memory Guanyl Nucleotide Binding Receptor Ligand Activity Regulation Of Defense Response Regulation Of Neurotransmitter Uptake Insulin Receptor Binding Regulation Of Membrane Potential Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Synaptic Transmission Neuronal Dense Core Vesicle Regulation Of Protein Transport G Protein-coupled Dopamine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Vocalization Behavior Regulation Of Innate Immune Response Cell Activation Involved In Immune Response Synapse Cell Junction Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Migration Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Positive Regulation Of Receptor Internalization Modulation Of Chemical Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Cell Motility Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Establishment Of Protein Localization	Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse
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