SSTR2 and SST

Number of citations of the paper that reports this interaction (PubMedID 1346068)
32

Data Source:
HPRD (in vivo)

		SSTR2	SST
Description		somatostatin receptor 2	somatostatin
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Neuron Projection	Extracellular Region Extracellular Space Cytosol Neuronal Cell Body GABA-ergic Synapse Neuronal Dense Core Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding PDZ Domain Binding Neuropeptide Binding	Hormone Activity Protein Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Somatostatin Signaling Pathway Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus	Hyperosmotic Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Response To Nutrient Digestion Negative Regulation Of Cell Population Proliferation Hormone-mediated Apoptotic Signaling Pathway Response To Xenobiotic Stimulus Response To Acidic PH Regulation Of Cell Migration Somatostatin Signaling Pathway Response To Amino Acid Response To Steroid Hormone Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates transcription of neuronal ligands
Drugs		Vapreotide Pasireotide Lanreotide Somatostatin Dotatate gallium Ga-68 Lutetium Lu 177 dotatate Edotreotide gallium Ga-68 Copper oxodotreotide Cu-64
Diseases
GWAS		Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Metabolite levels ( 23823483)	Pursuit maintenance gain ( 29064472) Skin pigmentation ( 28300201)
Interacting Genes		10 interacting genes: APP CORT DRD2 GNA14 GNAI1 PIK3R1 PTPN6 SHANK1 SHANK2 SST	6 interacting genes: PDIA2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
Entrez ID		6752	6750
HPRD ID		01674	08920
Ensembl ID		ENSG00000180616	ENSG00000157005
Uniprot IDs		P30874	P61278
PDB IDs		7T10 7T11 7UL5 7WIC 7WIG 7WJ5 7XAT 7XAU 7XAV 7XMR 7Y24 7Y26 7Y27 7YAC 7YAE	2MI1 7T10 7WIC 7WJ5 7XAT 7XMR 7XMS 7Y27
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Associative Learning Ionotropic Glutamate Receptor Binding Adult Behavior Dendritic Spine Learning Synaptic Receptor Adaptor Activity Regulation Of Biological Quality Synapse Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Learning Or Memory Cognition Chemical Synaptic Transmission Cell Surface Receptor Signaling Pathway Trans-synaptic Signaling Signal Transduction Synaptic Signaling SH3 Domain Binding Memory Guanyl Nucleotide Binding Receptor Ligand Activity Regulation Of Defense Response Regulation Of Neurotransmitter Uptake Insulin Receptor Binding Regulation Of Membrane Potential Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Synaptic Transmission Neuronal Dense Core Vesicle Regulation Of Protein Transport G Protein-coupled Dopamine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Vocalization Behavior Regulation Of Innate Immune Response Cell Activation Involved In Immune Response Synapse Cell Junction Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Migration Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Positive Regulation Of Receptor Internalization Modulation Of Chemical Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Cell Motility Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Establishment Of Protein Localization	Somatostatin Receptor Activity Somatostatin Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Neuron Projection Hormone-mediated Signaling Pathway G Protein-coupled Receptor Activity Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of Cell Population Proliferation G Protein-coupled Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Response To Glucocorticoid Cellular Response To Lipid Response To Corticosteroid Response To Steroid Hormone Cellular Response To Estradiol Stimulus Response To Lipid Regulation Of Cell Population Proliferation Cellular Response To Hormone Stimulus Response To Estradiol Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Response To Hormone Hormone-mediated Apoptotic Signaling Pathway RNA Strand Annealing Activity Nuclear Pore Localization Intracellular Membraneless Organelle Protein Retention In ER Lumen Positive Regulation Of Long-term Neuronal Synaptic Plasticity Disulfide Oxidoreductase Activity Nuclear Pore Complex Assembly Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Maintenance Of Protein Localization In Endoplasmic Reticulum Protein Folding In Endoplasmic Reticulum Nuclear Pore Organization Costamere Ribonucleoprotein Granule Translation Regulator Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Pore Complex Assembly Skeletal Muscle Organ Development Protein Disulfide Isomerase Activity
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