SSTR2 and CORT

Number of citations of the paper that reports this interaction (PubMedID 9125122)
0

Data Source:
BioGRID (unspecified method)
HPRD (in vivo)

		SSTR2	CORT
Description		somatostatin receptor 2	cortistatin
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Neuron Projection	Extracellular Region Extracellular Space Synapse
	Molecular Function	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding PDZ Domain Binding Neuropeptide Binding	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Somatostatin Signaling Pathway Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Cell Migration
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Vapreotide Pasireotide Lanreotide Somatostatin Dotatate gallium Ga-68 Lutetium Lu 177 dotatate Edotreotide gallium Ga-68 Copper oxodotreotide Cu-64
Diseases
GWAS		Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Metabolite levels ( 23823483)	Male-pattern baldness ( 28196072)
Interacting Genes		10 interacting genes: APP CORT DRD2 GNA14 GNAI1 PIK3R1 PTPN6 SHANK1 SHANK2 SST	7 interacting genes: GHSR MRGPRX2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
Entrez ID		6752	1325
HPRD ID		01674	04150
Ensembl ID		ENSG00000180616	ENSG00000241563
Uniprot IDs		P30874	O00230 Q8IUV6
PDB IDs		7T10 7T11 7UL5 7WIC 7WIG 7WJ5 7XAT 7XAU 7XAV 7XMR 7Y24 7Y26 7Y27 7YAC 7YAE	7S8L 7S8M 7VDL 7VV4 8X8L
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Binding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Associative Learning Ionotropic Glutamate Receptor Binding Adult Behavior Dendritic Spine Learning Synaptic Receptor Adaptor Activity Regulation Of Biological Quality Synapse Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Learning Or Memory Cognition Chemical Synaptic Transmission Cell Surface Receptor Signaling Pathway Trans-synaptic Signaling Signal Transduction Synaptic Signaling SH3 Domain Binding Memory Guanyl Nucleotide Binding Receptor Ligand Activity Regulation Of Defense Response Regulation Of Neurotransmitter Uptake Insulin Receptor Binding Regulation Of Membrane Potential Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Synaptic Transmission Neuronal Dense Core Vesicle Regulation Of Protein Transport G Protein-coupled Dopamine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Vocalization Behavior Regulation Of Innate Immune Response Cell Activation Involved In Immune Response Synapse Cell Junction Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Migration Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Positive Regulation Of Receptor Internalization Modulation Of Chemical Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Cell Motility Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Establishment Of Protein Localization	Somatostatin Receptor Activity Somatostatin Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Activity Hormone-mediated Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neuron Projection Response To Glucocorticoid Response To Corticosteroid Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of Cell Population Proliferation Response To Lipid Cellular Response To Steroid Hormone Stimulus Regulation Of Cell Population Proliferation Cellular Response To Hormone Stimulus Response To Estradiol Response To Hormone Signal Transduction Plasma Membrane Cellular Response To Estradiol Stimulus Positive Regulation Of Cytokinesis Growth Hormone Secretagogue Receptor Activity Ghrelin Secretion Mast Cell Secretagogue Receptor Activity Regulation Of Cytokinesis Positive Regulation Of Cell Division Negative Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Hindgut Contraction Positive Regulation Of Small Intestinal Transit Growth Hormone-releasing Hormone Receptor Activity Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Eating Behavior Regulation Of Gastric Motility Positive Regulation Of Response To Food Positive Regulation Of Appetite Membrane Regulation Of Insulin Secretion Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Hormone-mediated Apoptotic Signaling Pathway Regulation Of Cell Division Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Norepinephrine Secretion Growth Hormone Secretion Regulation Of Peptide Hormone Secretion Negative Regulation Of Macrophage Apoptotic Process
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