SSRP1 and H2AFX

Number of citations of the paper that reports this interaction (PMID 18406329)
45

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SSRP1	H2AFX
Gene Name		structure specific recognition protein 1	H2A histone family, member X
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm	Chromosome, Telomeric Region Nucleosome Nuclear Chromatin Condensed Nuclear Chromosome Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Replication Fork Site Of Double-strand Break Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding	DNA Binding Damaged DNA Binding Protein Binding Enzyme Binding Histone Binding Protein Heterodimerization Activity
	Biological Process	DNA Replication DNA Repair Chromatin Remodeling Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Positive Regulation Of Viral Transcription	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Nucleosome Assembly Cellular Response To DNA Damage Stimulus Spermatogenesis Response To Ionizing Radiation Positive Regulation Of DNA Repair Meiotic Cell Cycle
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends RNF mutants show enhanced WNT signaling and proliferation Homologous recombination repair of replication-independent double-strand breaks ATM mediated phosphorylation of repair proteins DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance ATM mediated response to DNA double-strand break misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Chromatin organization formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Senescence-Associated Secretory Phenotype (SASP) Chromatin modifying enzymes Recruitment of repair and signaling proteins to double-strand breaks SIRT1 negatively regulates rRNA Expression Condensation of Prophase Chromosomes MRN complex relocalizes to nuclear foci RNA Polymerase I Promoter Clearance Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks M Phase Telomere Maintenance Nucleosome assembly XAV939 inhibits tankyrase, stabilizing AXIN Double-Strand Break Repair DNA methylation Transcriptional regulation by small RNAs Meiotic recombination RNA Polymerase I Transcription Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic PRC2 methylates histones and DNA RMTs methylate histone arginines TCF dependent signaling in response to WNT Oxidative Stress Induced Senescence Homologous Recombination Repair RNA Polymerase I Promoter Opening Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: CHD1 CHMP1B CSNK2A1 DHX9 EXOSC10 H2AFX H3F3A HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE MCM4 MYCBP NEK9 RAN ROBO2 SPI1 SREK1 SRF SUMO1	45 interactors: A2M ACTB ALG9 ATM ATR BARD1 BMI1 BRCA1 BRCA2 BRD1 CALM1 COPG1 DDX21 DHX9 KAT5 MASP1 MCPH1 MDC1 MRE11A NBN NCL NGFR OTUB1 PAXIP1 PBK PPP1CA PPP2R4 PRKDC QARS RNF168 RNF8 RPS6KA3 SMARCA4 SSRP1 SUPT16H SUPT5H TAF1C TAF5L TERF2 TIAM2 TOPORS TP53BP1 TSSK6 WRN XRCC6
Entrez ID		6749	3014
HPRD ID		05061	03465
Ensembl ID		ENSG00000149136	ENSG00000188486
Uniprot IDs		Q08945	P16104
PDB IDs			2D31 2DYP 3SHV 3SQD 3SZM 3U3Z
Enriched GO Terms of Interacting Partners?		DNA Conformation Change Chromosome Organization Organelle Organization Nucleosome Assembly Chromatin Assembly Nucleobase-containing Compound Metabolic Process Nucleosome Organization DNA Methylation On Cytosine Chromatin Assembly Or Disassembly Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein-DNA Complex Assembly Chromatin Silencing At RDNA Cellular Nitrogen Compound Metabolic Process DNA Packaging Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Nitrogen Compound Metabolic Process Chromatin Silencing Gene Expression DNA Metabolic Process DNA Methylation Mitotic Cell Cycle DNA Replication-dependent Nucleosome Assembly DNA Duplex Unwinding DNA Geometric Change DNA Modification Cell Cycle Gene Silencing Regulation Of Gene Expression Positive Regulation Of Cell Growth Nucleus Organization Cellular Macromolecular Complex Assembly Cell Cycle Process Mitotic Cell Cycle Process Apoptotic Process Involved In Development DNA Replication-independent Nucleosome Assembly Olfactory Bulb Development Regulation Of Cellular Component Organization Olfactory Lobe Development Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Patterning Of Blood Vessels Positive Regulation Of Growth Contractile Actin Filament Bundle Assembly Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	DNA Metabolic Process Double-strand Break Repair DNA Repair Cellular Response To DNA Damage Stimulus Chromosome Organization DNA Recombination Organelle Organization Cellular Response To Stress Response To Ionizing Radiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Radiation Chromatin Organization Response To Stress Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Telomere Maintenance Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of Protein Metabolic Process Cellular Metabolic Process Histone Modification Signal Transduction By P53 Class Mediator Response To Stimulus Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Cellular Response To Stimulus Cellular Protein Modification Process DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification DNA Damage Checkpoint Peptidyl-lysine Modification Cell Cycle Process Regulation Of Cellular Protein Metabolic Process DNA Replication Regulation Of Gene Expression Response To Gamma Radiation Negative Regulation Of Protein Metabolic Process Histone Acetylation Double-strand Break Repair Via Nonhomologous End Joining
Tagcloud ?		coordinates cryptic displacement facilitates fact h2b h3k36me3 hypb intragenic kmt3a lys36 mammals methyltransferase modulates nucleosome nucleosomes observe occupancy positioned prevents recruitment repressing set2 setd2 spt16 spurious templates termed trimethylated
Tagcloud (Difference) ?		coordinates cryptic displacement facilitates fact h2b h3k36me3 hypb intragenic kmt3a lys36 mammals methyltransferase modulates nucleosome nucleosomes observe occupancy positioned prevents recruitment repressing set2 setd2 spt16 spurious templates termed trimethylated
Tagcloud (Intersection) ?