SSRP1 and SRF

Number of citations of the paper that reports this interaction (PMID 10336466)
9

Data Source:
HPRD (in vivo)

		SSRP1	SRF
Gene Name		structure specific recognition protein 1	serum response factor (c-fos serum response element-binding transcription factor)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm	Nuclear Chromatin Nucleus Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Serum Response Element Binding Chromatin DNA Binding Protein Homodimerization Activity
	Biological Process	DNA Replication DNA Repair Chromatin Remodeling Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Positive Regulation Of Viral Transcription	Patterning Of Blood Vessels Response To Hypoxia Mesoderm Formation Neuron Migration Trophectodermal Cell Differentiation Heart Looping Morphogenesis Of An Epithelial Sheet Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Transcription From RNA Polymerase II Promoter Cell-matrix Adhesion Heart Development Long-term Memory Negative Regulation Of Cell Proliferation Associative Learning Response To Toxic Substance Response To Hormone Epithelial Structure Maintenance Positive Regulation Of Transcription Via Serum Response Element Binding Hippocampus Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Contractile Actin Filament Bundle Assembly Regulation Of Cell Adhesion Platelet Activation Platelet Formation Negative Regulation Of Cell Migration Neuron Projection Development Regulation Of Water Loss Via Skin Response To Cytokine Megakaryocyte Development Dorsal Aorta Morphogenesis MRNA Transcription From RNA Polymerase II Promoter Stress Fiber Assembly Skin Morphogenesis Positive Thymic T Cell Selection Sarcomere Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Transcription By Glucose Muscle Cell Cellular Homeostasis Developmental Growth Neuron Development Erythrocyte Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Filopodium Assembly Cardiac Myofibril Assembly Angiogenesis Involved In Wound Healing Hematopoietic Stem Cell Differentiation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Long Term Synaptic Depression Heart Trabecula Formation Cardiac Vascular Smooth Muscle Cell Differentiation Eyelid Development In Camera-type Eye Tight Junction Assembly Cellular Response To Glucose Stimulus Primitive Streak Formation Epithelial Cell-cell Adhesion Cellular Senescence Negative Regulation Of Beta-amyloid Clearance
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: CHD1 CHMP1B CSNK2A1 DHX9 EXOSC10 H2AFX H3F3A HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE MCM4 MYCBP NEK9 RAN ROBO2 SPI1 SREK1 SRF SUMO1	72 interactors: ALDH3A1 ASCC1 ASCC2 ASCC3 ATF6 BARX2 CAMK2A CASP3 CASP6 CASP7 CASP8 CASP9 CD63 CEBPB CIRBP CNTN2 CREB1 CREBBP CRIP2 CSNK2A1 ELK1 ELK4 ETV4 FHL1 FHL2 FHL3 FHL5 FLI1 GATA4 GTF2F1 GTF2I HDAC4 HMGA1 HOPX KAT5 KDM6A MAPKAPK2 MINPP1 MKL1 MKL2 MYOCD MYOD1 MYOG NCOA1 NCOA6 NCOR2 NFKB1 NFYA NKX2-3 NKX2-5 NKX3-1 OGT PML PRKDC PRRX1 PYCARD RARG REL RELA RPS6KA1 RXRA RXRG SHBG SP1 SRC SRFBP1 SSRP1 TCF3 TEAD1 TRIM63 UBE2I ZIC3
Entrez ID		6749	6722
HPRD ID		05061	02788
Ensembl ID		ENSG00000149136	ENSG00000112658
Uniprot IDs		Q08945	F5H6V4 P11831
PDB IDs			1HBX 1K6O 1SRS
Enriched GO Terms of Interacting Partners?		DNA Conformation Change Chromosome Organization Organelle Organization Nucleosome Assembly Chromatin Assembly Nucleobase-containing Compound Metabolic Process Nucleosome Organization DNA Methylation On Cytosine Chromatin Assembly Or Disassembly Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein-DNA Complex Assembly Chromatin Silencing At RDNA Cellular Nitrogen Compound Metabolic Process DNA Packaging Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Nitrogen Compound Metabolic Process Chromatin Silencing Gene Expression DNA Metabolic Process DNA Methylation Mitotic Cell Cycle DNA Replication-dependent Nucleosome Assembly DNA Duplex Unwinding DNA Geometric Change DNA Modification Cell Cycle Gene Silencing Regulation Of Gene Expression Positive Regulation Of Cell Growth Nucleus Organization Cellular Macromolecular Complex Assembly Cell Cycle Process Mitotic Cell Cycle Process Apoptotic Process Involved In Development DNA Replication-independent Nucleosome Assembly Olfactory Bulb Development Regulation Of Cellular Component Organization Olfactory Lobe Development Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Patterning Of Blood Vessels Positive Regulation Of Growth Contractile Actin Filament Bundle Assembly Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Organ Development Cell Differentiation Developmental Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Tissue Development Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Response To Lipid Anatomical Structure Development Regulation Of Cellular Process Anatomical Structure Morphogenesis System Development Response To Hormone Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Heart Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Multicellular Organismal Development Negative Regulation Of Gene Expression Response To Steroid Hormone Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process
Tagcloud ?		coordinates cryptic displacement facilitates fact h2b h3k36me3 hypb intragenic kmt3a lys36 mammals methyltransferase modulates nucleosome nucleosomes observe occupancy positioned prevents recruitment repressing set2 setd2 spt16 spurious templates termed trimethylated	ali bellan biol chem classes coactivator coexpression concluded cooperate creb element finding glutathione harel homologue hybrid mammalian potentiated pull ramirez robin src sre steroid synergistically transactivations transferase trouche yeast
Tagcloud (Difference) ?		coordinates cryptic displacement facilitates fact h2b h3k36me3 hypb intragenic kmt3a lys36 mammals methyltransferase modulates nucleosome nucleosomes observe occupancy positioned prevents recruitment repressing set2 setd2 spt16 spurious templates termed trimethylated	ali bellan biol chem classes coactivator coexpression concluded cooperate creb element finding glutathione harel homologue hybrid mammalian potentiated pull ramirez robin src sre steroid synergistically transactivations transferase trouche yeast
Tagcloud (Intersection) ?