SSRP1 and ROBO2

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		SSRP1	ROBO2
Name		structure specific recognition protein 1	roundabout guidance receptor 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus FACT Complex	Plasma Membrane Cell Surface Membrane Axolemma Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding RNA Binding Protein Binding Nucleosome Binding Histone Binding	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding
	Biological Process	DNA Replication DNA Repair Nucleosome Assembly Nucleosome Disassembly DNA Damage Response Regulation Of Chromatin Organization	Metanephros Development Ureteric Bud Development Heart Induction Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Cell Differentiation Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Tube Development Aorta Development Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Cell-cell Adhesion
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5 Formation of the ureteric bud
Diseases		None	Vesicoureteral reflux
GWAS		No GWAS studies recorded	Bell's palsy ( 33602968 ) Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965 ) Body size at age 10 ( 32376654 ) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Chronotype ( 30696823 ) Cortical surface area (MOSTest) ( 32665545 ) Expressive vocabulary in infants ( 25226531 ) Familial lung adenocarcinoma ( 29924316 ) Gut microbiota alpha diversity (Chao1 index) ( 33208821 ) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821 ) Hand grip strength ( 29691431 ) Hip circumference ( 28552196 ) LDL cholesterol levels in HIV infection ( 33109212 ) Left-handedness ( 32989287 ) Metabolite levels ( 23823483 ) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000 ) Morning person ( 30696823 ) Periodontitis (PAL4Q3) ( 24024966 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Type 2 diabetes ( 30297969 )
Interacting Genes		19 interacting genes: AURKA CEBPA CHD1 CHMP1B CSNK2A1 DHX9 EXOSC10 H3-3A MCM4 MYCBP NEK9 PTEN RAN ROBO2 SPI1 SREK1 SRF SUMO2 UBE2I	18 interacting genes: BNIP3L CENPU CPE GPR152 HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TMEM237 TRIM13 UBQLN4
Entrez ID		6749	6092
HPRD ID		05061	11895
Ensembl ID		ENSG00000149136	ENSG00000185008
Uniprot IDs		Q08945	A0A8Q3SIU0 A0A8Q3SIW8 A0A8Q3WLE3 A0A994J7I9 F8W703 H7C4J7 H7C4U9 H7C4W9 Q9HCK4
PDB IDs		4IFS 5UMR 5UMS 5VWE 6L1E 6L1R 6L34 6UPK 6UPL 9EH2	1UEM 1UJT 2EDJ 5NOI 6I9S 6IAA
GO Terms Enriched among Interactors		Nucleoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteolysis Nucleotide Binding Importin-alpha Family Protein Binding Membrane Assembly Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process STAT Family Protein Binding Positive Regulation Of Protein Catabolic Process Spindle Assembly Involved In Female Meiosis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Nuclear Pore Chromatin DNA Binding Meiotic Spindle Assembly Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Interleukin-6-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Development Membraneless Organelle Assembly SUMO Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Meiotic Spindle Organization Positive Regulation Of Catabolic Process Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Membrane Reassembly Histone Deacetylase Binding Positive Regulation Of RNA Metabolic Process Osteoblast Differentiation Presynaptic Cytosol Granulocyte Differentiation Protein Heterodimerization Activity ATP Binding Mitotic Cell Cycle Postsynaptic Cytosol Regulation Of Axonogenesis Viral Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process	Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Aortic Valve Morphogenesis Ventricular Septum Morphogenesis Regulation Of Negative Chemotaxis Negative Chemotaxis Roundabout Binding Response To Cortisol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Heart Valve Morphogenesis Regulation Of Cytokine-mediated Signaling Pathway Cardiac Septum Morphogenesis Axon Extension Involved In Axon Guidance Neuron Projection Guidance Axon Guidance Endothelial Cell Migration Pulmonary Valve Morphogenesis Chemotaxis Locomotion Regulation Of G Protein-coupled Receptor Signaling Pathway Apoptotic Process Involved In Development Regulation Of Macroautophagy Positive Regulation Of Secretion Of Lysosomal Enzymes Histone H2AS1 Kinase Activity Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Axon Extension Signal Transduction Negative Regulation Of Chemotaxis Transport Vesicle Membrane Nuclear Receptor Activity Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Histone H3S28 Kinase Activity Negative Regulation Of Retinal Ganglion Cell Axon Guidance Aldehyde Dehydrogenase (NADP+) Activity 11-cis-retinol Dehydrogenase (NADP+) Activity Nuclear Proteasome Complex Protein Localization To Secretory Granule Negative Regulation Of Negative Chemotaxis Positive Regulation Of Axonogenesis