SSRP1 and ROBO2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SSRP1	ROBO2
Gene Name		structure specific recognition protein 1	roundabout, axon guidance receptor, homolog 2 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm	Cell Surface Integral Component Of Membrane Axolemma Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding
	Biological Process	DNA Replication DNA Repair Chromatin Remodeling Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Positive Regulation Of Viral Transcription	Metanephros Development Ureteric Bud Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Apoptotic Process Involved In Luteolysis
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor
Drugs
Diseases
GWAS			Brain imaging in schizophrenia (interaction) ( 19023125) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)
Protein-Protein Interactions		20 interactors: CHD1 CHMP1B CSNK2A1 DHX9 EXOSC10 H2AFX H3F3A HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE MCM4 MYCBP NEK9 RAN ROBO2 SPI1 SREK1 SRF SUMO1	16 interactors: BNIP3L CENPU CPE HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TRIM13 UBQLN4
Entrez ID		6749	6092
HPRD ID		05061	11895
Ensembl ID		ENSG00000149136	ENSG00000185008
Uniprot IDs		Q08945	Q9HCK4
PDB IDs			1UEM 1UJT 2EDJ
Enriched GO Terms of Interacting Partners?		DNA Conformation Change Chromosome Organization Organelle Organization Nucleosome Assembly Chromatin Assembly Nucleobase-containing Compound Metabolic Process Nucleosome Organization DNA Methylation On Cytosine Chromatin Assembly Or Disassembly Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein-DNA Complex Assembly Chromatin Silencing At RDNA Cellular Nitrogen Compound Metabolic Process DNA Packaging Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Nitrogen Compound Metabolic Process Chromatin Silencing Gene Expression DNA Metabolic Process DNA Methylation Mitotic Cell Cycle DNA Replication-dependent Nucleosome Assembly DNA Duplex Unwinding DNA Geometric Change DNA Modification Cell Cycle Gene Silencing Regulation Of Gene Expression Positive Regulation Of Cell Growth Nucleus Organization Cellular Macromolecular Complex Assembly Cell Cycle Process Mitotic Cell Cycle Process Apoptotic Process Involved In Development DNA Replication-independent Nucleosome Assembly Olfactory Bulb Development Regulation Of Cellular Component Organization Olfactory Lobe Development Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Patterning Of Blood Vessels Positive Regulation Of Growth Contractile Actin Filament Bundle Assembly Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Negative Chemotaxis Cell Migration Involved In Sprouting Angiogenesis Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Regulation Of Cytokine-mediated Signaling Pathway Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Regulation Of Negative Chemotaxis Luteolysis Response To Cortisol Sprouting Angiogenesis Mammary Duct Terminal End Bud Growth Signal Transduction Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Response To Stimulus Olfactory Bulb Interneuron Development Axon Extension Involved In Axon Guidance Signaling Endothelial Cell Migration Cell Communication Chemotaxis Cerebral Cortex Tangential Migration Positive Regulation Of Cell Death Epithelial Cell Migration Epithelium Migration Olfactory Bulb Interneuron Differentiation Response To External Stimulus Axon Guidance Developmental Growth Involved In Morphogenesis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Chemotaxis Response To Stimulus Apoptotic Process Involved In Development Ameboidal-type Cell Migration Response To Steroid Hormone Regulation Of Cellular Process Regulation Of Protein Metabolic Process Forebrain Neuron Development Substrate-dependent Cell Migration Apoptotic Process Axonogenesis Olfactory Bulb Development Axon Extension Programmed Cell Death Cell Surface Receptor Signaling Pathway Olfactory Lobe Development Cell Death
Tagcloud ?		coordinates cryptic displacement facilitates fact h2b h3k36me3 hypb intragenic kmt3a lys36 mammals methyltransferase modulates nucleosome nucleosomes observe occupancy positioned prevents recruitment repressing set2 setd2 spt16 spurious templates termed trimethylated	arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Difference) ?		coordinates cryptic displacement facilitates fact h2b h3k36me3 hypb intragenic kmt3a lys36 mammals methyltransferase modulates nucleosome nucleosomes observe occupancy positioned prevents recruitment repressing set2 setd2 spt16 spurious templates termed trimethylated	arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Intersection) ?