TROVE2 and TRIM21

Number of citations of the paper that reports this interaction (PMID 11251884)
2

Data Source:
HPRD (in vivo)

		TROVE2	TRIM21
Gene Name		TROVE domain family, member 2	tripartite motif containing 21
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Ribonucleoprotein Complex	Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding U2 SnRNA Binding Metal Ion Binding	DNA Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Identical Protein Binding
	Biological Process	Immune System Development Transcription From RNA Polymerase III Promoter Smoothened Signaling Pathway Response To UV Cilium Morphogenesis	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Protein Ubiquitination Cytokine-mediated Signaling Pathway Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of Cell Cycle Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autoubiquitination Interferon-gamma-mediated Signaling Pathway Protein Trimerization Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways			Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses Interferon Signaling Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: RAB11FIP5 TRIM21	37 interactors: APC CASP8AP2 CDC34 CUL1 DAXX DCP2 DZIP3 FADD FBXW11 GRAP HLA-DRB1 IGHG1 IGHV4-31 IKBKB IRF8 MNAT1 NIF3L1 RBCK1 RNF111 SKP2 TRIM27 TRIM39 TRIM5 TRIM8 TROVE2 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2H UBE2I UBE2L3 USP15 USP2 USP4 YWHAZ
Entrez ID		6738	6737
HPRD ID		15964	00170
Ensembl ID		ENSG00000116747	ENSG00000132109
Uniprot IDs		P10155 Q5LJA0	P19474
PDB IDs			2IWG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Deubiquitination Positive Regulation Of Viral Entry Into Host Cell Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Protein Deubiquitination Cellular Response To Acidic PH Cellular Response To PH Negative Regulation Of Viral Release From Host Cell Response To Acidic PH Regulation Of Protein Localization To Cell Surface Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Protein Destabilization Protein Trimerization Response To PH Protein Monoubiquitination Insulin Secretion Protein Autoubiquitination Regulated Secretory Pathway Cellular Response To Glucose Stimulus Negative Regulation Of NF-kappaB Transcription Factor Activity Peptide Hormone Secretion Peptide Secretion Regulation Of Viral Transcription Positive Regulation Of Viral Process Negative Regulation Of Viral Process Cellular Glucose Homeostasis Cellular Response To Organic Substance Cellular Response To Carbohydrate Stimulus Positive Regulation Of Type I Interferon Production Hormone Secretion Hormone Transport Peptide Transport Regulation Of Type I Interferon Production Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Secretion Interferon-gamma-mediated Signaling Pathway Amide Transport Response To Glucose Response To Organic Substance Regulation Of Protein Stability Cellular Response To Interferon-gamma Regulation Of Viral Process Response To Interferon-gamma Protein Polyubiquitination Response To Carbohydrate Glucose Homeostasis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Catabolic Process Cellular Protein Modification Process Proteolysis Regulation Of Protein Ubiquitination Protein Metabolic Process Regulation Of Proteolysis Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Mitotic Cell Cycle Process Protein K48-linked Ubiquitination Regulation Of Protein Metabolic Process Cell Cycle Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Mitotic Cell Cycle Innate Immune Response Cell Cycle Process Immune Response-regulating Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cell Communication Activation Of Innate Immune Response Regulation Of Signaling Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction Positive Regulation Of Ligase Activity Response To Stimulus
Tagcloud ?			2ms 3ms 440ms addressable adjusting albia antibodies bead confounders corrected ekg erythematosus immunoassay lupus multicenter prolongation prolonged qt qtc reasons repolarization resting ro ro52 ro60 separately ss ssc univariate
Tagcloud (Difference) ?			2ms 3ms 440ms addressable adjusting albia antibodies bead confounders corrected ekg erythematosus immunoassay lupus multicenter prolongation prolonged qt qtc reasons repolarization resting ro ro52 ro60 separately ss ssc univariate
Tagcloud (Intersection) ?