SRP72 and FCHSD2

Number of citations of the paper that reports this interaction (PubMedID 18654987)
0

Data Source:
BioGRID (two hybrid)

		SRP72	FCHSD2
Description		signal recognition particle 72	FCH and double SH3 domains 2
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Signal Recognition Particle Ribonucleoprotein Complex	Cytoplasm Plasma Membrane Clathrin-coated Pit Membrane Neuromuscular Junction Stereocilium Cell Projection Recycling Endosome Anchoring Junction Stereocilium Shaft
	Molecular Function	RNA Binding Signal Recognition Particle Binding Protein Binding 7S RNA Binding TPR Domain Binding Ribosome Binding	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane	Endocytosis Neuromuscular Synaptic Transmission Protein Transport Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Membrane Organization Clathrin-dependent Endocytosis Regulation Of Actin Filament Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378)	Albumin-globulin ratio ( 29403010) Crohn's disease ( 23266558 23850713) Endometrial cancer (endometrioid histology) ( 30093612) Health literacy ( 31250787) Nicotine dependence symptom count ( 25555482) Serum total protein levels ( 29403010) Systemic lupus erythematosus ( 26663301 33272962)
Interacting Genes		12 interacting genes: CASP3 CASP6 CDC42 CEBPA FCHSD2 HSPB1 OGT PYGM SKIL SRP68 SULT2B1 TULP3	52 interacting genes: ABCF3 ACAP1 ANKS1A ATPAF2 BORCS6 C9orf78 CASK CCDC120 CCDC158 CCDC183 CCDC85B CCT2 CFAP36 CHKA CIMIP6 CTAG1A CTAG1B DAPP1 ENKD1 FAM9B GPRASP2 HDAC4 HGS HOMER1 HSP90AB1 HSPA5 HTRA1 ITSN1 ITSN2 KIFC3 LCA5L LDOC1 MNS1 MRFAP1 MSL1 MTUS2 PDE4DIP PRKAR1B RINT1 SASS6 SERTAD3 SH2D4A SH3BGR SRP72 TLE5 TSGA10IP USHBP1 VCPIP1 VPS37C WAS WASL ZNF587
Entrez ID		6731	9873
HPRD ID		03671	13321
Ensembl ID		ENSG00000174780	ENSG00000137478
Uniprot IDs		O76094 V9HWK0	O94868
PDB IDs		5M72 5M73 5WRV 5WRW 7NFX 8QVW 8QVX	2DL5 2DL7 6GBU
Enriched GO Terms of Interacting Partners?		Cellular Response To Staurosporine Pyroptotic Inflammatory Response Epithelial Cell Differentiation Multicellular Organismal-level Homeostasis Endothelin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Protein-containing Complex Binding Epithelial Cell Maturation Positive Regulation Of Chemotaxis Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Necroptotic Process Embryonic Organ Development Cellular Response To Alkaloid Signal Transduction Intrinsic Apoptotic Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Homeostatic Process Protein Processing Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Developmental Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Programmed Cell Death Cytoplasm Epithelial Cell Apoptotic Process Inflammatory Response Cellular Developmental Process Response To Cytokine Positive Regulation Of Organelle Organization Regulation Of Cell Migration Macrophage Differentiation Protein Domain Specific Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cell Tip Growth Hormonal Regulation Of The Force Of Heart Contraction Regulation Of Chemotaxis Lung Alveolus Development Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Stereocilium Shaft Epithelium Development Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Migration Response To Peptide Regulation Of Cell Motility Vasculature Development	TPR Domain Binding Clathrin-dependent Synaptic Vesicle Endocytosis Cytoplasm
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