SRP72 and FCHSD2

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		SRP72	FCHSD2
Gene Name		signal recognition particle 72kDa	FCH and double SH3 domains 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Plasma Membrane
	Molecular Function	Signal Recognition Particle Binding 7S RNA Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Translation SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Response To Drug Cellular Protein Metabolic Process
Pathways		Translation SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378)	Crohn's disease ( 23266558)
Protein-Protein Interactions		5 interactors: CASP3 CASP6 FCHSD2 SKIL SRP68	25 interactors: ABCF3 C2orf73 C9orf78 CASK CCDC158 CCDC85B CCT2 CFAP36 CHKA DAPP1 FAM9B HSP90AB1 HSPA5 HTRA1 ITSN1 ITSN2 KIFC3 MSL1 MTUS2 PDE4DIP SH3BGR SRP72 VCPIP1 WAS WASL
Entrez ID		6731	9873
HPRD ID		03671	13321
Ensembl ID			ENSG00000137478
Uniprot IDs		O76094	E9PG19 O94868
PDB IDs			2DL5 2DL7
Enriched GO Terms of Interacting Partners?		Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epithelial Cell Differentiation Lymphocyte Homeostasis Execution Phase Of Apoptosis Leukocyte Homeostasis Epithelium Development Homeostasis Of Number Of Cells Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Glial Cell Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Tissue Development Protein Heterotrimerization Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Negative Regulation Of Cell Cycle Negative Regulation Of B Cell Proliferation Protein Homotrimerization Apoptotic DNA Fragmentation Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Platelet Formation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Programmed Cell Death Response To Growth Factor Platelet Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cell Death Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Hippo Signaling Response To Cytokine Apoptotic Nuclear Changes Release Of Cytochrome C From Mitochondria Lens Fiber Cell Differentiation Protein Trimerization Regulation Of Activated T Cell Proliferation B Cell Homeostasis T Cell Homeostasis Negative Regulation Of B Cell Activation	Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Arp2/3 Complex-mediated Actin Nucleation Endocytosis Regulation Of Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Toxin Transport Cellular Response To Interleukin-4 Vesicle-mediated Transport Response To Interleukin-4 Regulation Of Protein Folding In Endoplasmic Reticulum Protein Complex Assembly Phagocytosis Actin Filament-based Movement Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Golgi Organization Endoplasmic Reticulum Membrane Fusion Negative Regulation Of Membrane Tubulation Cerebellum Structural Organization Transport Actin Polymerization Or Depolymerization Cellular Protein Complex Assembly Zonula Adherens Maintenance Vesicle Transport Along Actin Filament Cellular Component Assembly Ephrin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Golgi Reassembly Dentinogenesis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Axon Guidance Protein Localization To Endoplasmic Reticulum Positive Regulation Of Clathrin-mediated Endocytosis Movement Of Cell Or Subcellular Component Response To Unfolded Protein Immune Response-regulating Signaling Pathway Choline Metabolic Process Golgi Inheritance Protein K11-linked Deubiquitination
Tagcloud ?		aa alongside aplastic associate autosomal causative coimmunoprecipitation dominant elucidating epitope excreted exome haplotype heterozygous idiopathic incorrectly inheritance inherited localize myelodysplasia nascent particle pathophysiology screen simplex snp tagged telomerase
Tagcloud (Difference) ?		aa alongside aplastic associate autosomal causative coimmunoprecipitation dominant elucidating epitope excreted exome haplotype heterozygous idiopathic incorrectly inheritance inherited localize myelodysplasia nascent particle pathophysiology screen simplex snp tagged telomerase
Tagcloud (Intersection) ?