SRP72 and SKIL

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SRP72	SKIL
Description		signal recognition particle 72	SKI like proto-oncogene
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Signal Recognition Particle Ribonucleoprotein Complex	Acrosomal Vesicle Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm PML Body Protein-containing Complex
	Molecular Function	RNA Binding Signal Recognition Particle Binding Protein Binding 7S RNA Binding TPR Domain Binding Ribosome Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein-containing Complex Binding SMAD Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Formation Lymphocyte Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Skeletal Muscle Tissue Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Response To Cytokine Negative Regulation Of Cell Differentiation Response To Antibiotic Regulation Of Neurogenesis Positive Regulation Of Axonogenesis Regulation Of Cell Cycle Muscle Structure Development Lens Fiber Cell Differentiation Response To Growth Factor Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane	Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378)	Aspartate aminotransferase levels ( 33547301) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Prostate cancer ( 21743467)
Interacting Genes		12 interacting genes: CASP3 CASP6 CDC42 CEBPA FCHSD2 HSPB1 OGT PYGM SKIL SRP68 SULT2B1 TULP3	97 interacting genes: ASCC3 CAMSAP1 CBX4 CDC16 CDC27 CHD3 CHPF COL4A2 CPNE1 CPNE2 CPNE4 CXXC5 DEUP1 DHX30 DRC4 DRG1 DSCAM EEF1G EIF4G2 ESR1 FAF1 FBLN1 FN1 FZR1 GLUL GOLGB1 HEY1 HEYL HIPK1 HIPK3 HNRNPLL IL36RN KRT81 LRP1 MACF1 MORC4 MVP MYG1 NCOR1 NCOR2 NEFL NID1 NID2 NXF3 OIP5 PAPPA PIAS1 PIAS3 PIAS4 PLCD3 PPL PSG3 PSMC2 PTPRF PYCR2 RNF4 RPS27 SASH1 SETDB1 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMUG1 SMURF2 SNRNP70 SNX17 SPARCL1 SRP72 STK16 SVEP1 TDG TDP2 TFPI2 THAP5 THSD7A TLE5 TPM2 TRAK1 TRIM62 TRIM69 TSKU TTF2 UBE2I UIMC1 USP25 VPS28 XPA XRCC6 ZBTB3 ZBTB6 ZMYM2 ZMYM5 ZNF106 ZNF200 ZZEF1
Entrez ID		6731	6498
HPRD ID		03671	01319
Ensembl ID		ENSG00000174780	ENSG00000136603
Uniprot IDs		O76094 V9HWK0	P12757
PDB IDs		5M72 5M73 5WRV 5WRW 7NFX 8QVW 8QVX	3EQ5 5C4V
Enriched GO Terms of Interacting Partners?		Cellular Response To Staurosporine Pyroptotic Inflammatory Response Epithelial Cell Differentiation Multicellular Organismal-level Homeostasis Endothelin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Protein-containing Complex Binding Epithelial Cell Maturation Positive Regulation Of Chemotaxis Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Necroptotic Process Embryonic Organ Development Cellular Response To Alkaloid Signal Transduction Intrinsic Apoptotic Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Homeostatic Process Protein Processing Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Developmental Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Programmed Cell Death Cytoplasm Epithelial Cell Apoptotic Process Inflammatory Response Cellular Developmental Process Response To Cytokine Positive Regulation Of Organelle Organization Regulation Of Cell Migration Macrophage Differentiation Protein Domain Specific Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cell Tip Growth Hormonal Regulation Of The Force Of Heart Contraction Regulation Of Chemotaxis Lung Alveolus Development Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Stereocilium Shaft Epithelium Development Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Migration Response To Peptide Regulation Of Cell Motility Vasculature Development	PML Body Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Heteromeric SMAD Protein Complex SUMO Transferase Activity Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process SUMO Ligase Activity I-SMAD Binding Collagen Binding Regulation Of Macromolecule Metabolic Process Response To Transforming Growth Factor Beta Regulation Of MiRNA Transcription Protein Metabolic Process Metal Ion Binding Protein Modification By Small Protein Conjugation Nuclear Body Cell Surface Receptor Signaling Pathway Regulation Of Primary Metabolic Process SMAD Protein Signal Transduction Protein Sumoylation Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Zinc Ion Binding Regulation Of Metabolic Process Cytoplasm Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus SUMO Binding Homomeric SMAD Protein Complex Negative Regulation Of Transforming Growth Factor Beta Production Co-SMAD Binding Regulation Of Gene Expression Regulation Of Developmental Process Extracellular Matrix Structural Constituent Primary MiRNA Processing Positive Regulation Of Protein Sumoylation Regulation Of Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cytosol
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?