SRP72 and EDN2

		SRP72	EDN2
Description		signal recognition particle 72	endothelin 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Signal Recognition Particle Ribonucleoprotein Complex	Extracellular Region Extracellular Space
	Molecular Function	RNA Binding Signal Recognition Particle Binding Protein Binding 7S RNA Binding TPR Domain Binding Ribosome Binding	Hormone Activity Endothelin B Receptor Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane	Angiogenesis Temperature Homeostasis Vasculature Development Positive Regulation Of Leukocyte Chemotaxis Hormonal Regulation Of The Force Of Heart Contraction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Tip Growth Positive Regulation Of Heart Rate Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Cytokine-mediated Signaling Pathway Regulation Of Vasoconstriction Neutrophil Chemotaxis Neuron Projection Development Positive Regulation Of Prostaglandin Biosynthetic Process Macrophage Activation Vasoconstriction Endothelial Cell Migration Positive Regulation Of Smooth Muscle Contraction Macrophage Chemotaxis Lung Alveolus Development Axon Extension Positive Regulation Of Calcium-mediated Signaling Endothelin Receptor Signaling Pathway Energy Homeostasis Blood Vessel Diameter Maintenance
Pathways		SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378)	Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Phenylephrine infusion rate during anesthesia ( 31455332) PR interval ( 32439900) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		12 interacting genes: CASP3 CASP6 CDC42 CEBPA FCHSD2 HSPB1 OGT PYGM SKIL SRP68 SULT2B1 TULP3	3 interacting genes: CMA1 KEL MME
Entrez ID		6731	1907
HPRD ID		03671	07173
Ensembl ID		ENSG00000174780	ENSG00000127129
Uniprot IDs		O76094 V9HWK0	P20800
PDB IDs		5M72 5M73 5WRV 5WRW 7NFX 8QVW 8QVX
Enriched GO Terms of Interacting Partners?		Cellular Response To Staurosporine Pyroptotic Inflammatory Response Epithelial Cell Differentiation Multicellular Organismal-level Homeostasis Endothelin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Protein-containing Complex Binding Epithelial Cell Maturation Positive Regulation Of Chemotaxis Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Necroptotic Process Embryonic Organ Development Cellular Response To Alkaloid Signal Transduction Intrinsic Apoptotic Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Homeostatic Process Protein Processing Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Developmental Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphatidylinositol-3,4,5-trisphosphate Binding Regulation Of Programmed Cell Death Cytoplasm Epithelial Cell Apoptotic Process Inflammatory Response Cellular Developmental Process Response To Cytokine Positive Regulation Of Organelle Organization Regulation Of Cell Migration Macrophage Differentiation Protein Domain Specific Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cell Tip Growth Hormonal Regulation Of The Force Of Heart Contraction Regulation Of Chemotaxis Lung Alveolus Development Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Stereocilium Shaft Epithelium Development Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Migration Response To Peptide Regulation Of Cell Motility Vasculature Development	Angiotensin Maturation Protein Processing Peptide Binding Protein Maturation Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptide Metabolic Process Peptidase Activity Endopeptidase Activity Metalloendopeptidase Activity Neuropeptide Processing Metallopeptidase Activity Oligopeptidase Activity Creatinine Metabolic Process Hormone Metabolic Process Basement Membrane Disassembly Substance P Catabolic Process Exopeptidase Activity Cytokine Precursor Processing Regulation Of Axon Diameter Neuropeptide Catabolic Process Proteolysis Intracellular Magnesium Ion Homeostasis Signal Recognition Particle Bradykinin Catabolic Process Amyloid-beta Clearance By Cellular Catabolic Process Signal Recognition Particle Binding Signal Recognition Particle, Endoplasmic Reticulum Targeting 7S RNA Binding TPR Domain Binding Cellular Response To UV-A SRP-dependent Cotranslational Protein Targeting To Membrane Regulation Of Cell Projection Size Magnesium Ion Homeostasis Cardiolipin Binding Hydrolase Activity Response To UV-A Cellular Response To UV-B Hormone Catabolic Process Replicative Senescence Cotranslational Protein Targeting To Membrane Peptide Catabolic Process Neuron Projection Terminus Intracellular Chemical Homeostasis Regulation Of Hormone Levels Negative Regulation Of Potassium Ion Transmembrane Transport Response To UV-B Positive Regulation Of Long-term Synaptic Potentiation Amyloid-beta Metabolic Process Metallocarboxypeptidase Activity
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