SRP72 and CASP6

Number of citations of the paper that reports this interaction (PMID 9857079)
8

Data Source:
HPRD (in vitro)

		SRP72	CASP6
Gene Name		signal recognition particle 72kDa	caspase 6, apoptosis-related cysteine peptidase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Plasma Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Signal Recognition Particle Binding 7S RNA Binding Poly(A) RNA Binding	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding
	Biological Process	Translation SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Response To Drug Cellular Protein Metabolic Process	Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epithelial Cell Differentiation
Pathways		Translation SRP-dependent cotranslational protein targeting to membrane	Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Breakdown of the nuclear lamina Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378)
Protein-Protein Interactions		5 interactors: CASP3 CASP6 FCHSD2 SKIL SRP68	38 interactors: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 MAPK6 MAPT NEDD4 NUAK1 PCYT1A PIN1 PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM
Entrez ID		6731	839
HPRD ID		03671	03321
Ensembl ID			ENSG00000138794
Uniprot IDs		O76094	P55212
PDB IDs			1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA
Enriched GO Terms of Interacting Partners?		Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epithelial Cell Differentiation Lymphocyte Homeostasis Execution Phase Of Apoptosis Leukocyte Homeostasis Epithelium Development Homeostasis Of Number Of Cells Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Glial Cell Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Tissue Development Protein Heterotrimerization Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Negative Regulation Of Cell Cycle Negative Regulation Of B Cell Proliferation Protein Homotrimerization Apoptotic DNA Fragmentation Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Platelet Formation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Programmed Cell Death Response To Growth Factor Platelet Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cell Death Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Hippo Signaling Response To Cytokine Apoptotic Nuclear Changes Release Of Cytochrome C From Mitochondria Lens Fiber Cell Differentiation Protein Trimerization Regulation Of Activated T Cell Proliferation B Cell Homeostasis T Cell Homeostasis Negative Regulation Of B Cell Activation	Programmed Cell Death Cell Death Death Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Viral Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Tissue Development Response To Stimulus Heart Development Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Cell Communication Regulation Of Protein Kinase Activity Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Neuron Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Signaling Signaling Regulation Of Cell Death Anatomical Structure Morphogenesis Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Neuron Death Skin Development Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Myeloid Cell Differentiation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Organ Development Cell Differentiation Cellular Response To Stimulus Response To Stress Signal Transduction Positive Regulation Of Catalytic Activity Cell Development Positive Regulation Of Proteolysis Immune System Process Regulation Of Phosphorylation Anatomical Structure Development Cellular Response To Organic Substance
Tagcloud ?		aa alongside aplastic associate autosomal causative coimmunoprecipitation dominant elucidating epitope excreted exome haplotype heterozygous idiopathic incorrectly inheritance inherited localize myelodysplasia nascent particle pathophysiology screen simplex snp tagged telomerase	5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin
Tagcloud (Difference) ?		aa alongside aplastic associate autosomal causative coimmunoprecipitation dominant elucidating epitope excreted exome haplotype heterozygous idiopathic incorrectly inheritance inherited localize myelodysplasia nascent particle pathophysiology screen simplex snp tagged telomerase	5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin
Tagcloud (Intersection) ?