SHBG and MXD4

Number of citations of the paper that reports this interaction (PubMedID 15862967)
0

Data Source:
HPRD (two hybrid)

		SHBG	MXD4
Description		sex hormone binding globulin	MAX dimerization protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Exosome	Chromatin Nucleus Nucleoplasm
	Molecular Function	Steroid Binding Androgen Binding Protein Binding Lipid Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways			Nuclear signaling by ERBB4
Drugs		Masoprocol Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Toremifene Estrone Tamoxifen Clomifene Dienestrol Hesperetin Zinc Genistein Naringenin Quercetin 4'-Hydroxyflavanone Afimoxifene Estriol Phenolphthalein Norethynodrel Dioxybenzone Zeranol Gestrinone Equol Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate
Diseases
GWAS		A body shape index ( 34021172) Androgen levels ( 22936694) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Estradiol levels ( 34255042) Glycated hemoglobin levels ( 34059833) Heel bone mineral density ( 30598549) Hormone measurements ( 24049095) Medication use (calcium channel blockers) ( 31015401) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 27863252) Refractive error ( 32231278) Sex hormone levels ( 26014426) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	HDL cholesterol levels ( 32203549) Monocyte count ( 32888494)
Interacting Genes		62 interacting genes: A2M ACP3 ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5F1A AZGP1 CD177 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HDHD5 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SPMIP6 SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A	6 interacting genes: MAX MLX SHBG SIN3A SMC3 TCP10L
Entrez ID		6462	10608
HPRD ID		01646	10103
Ensembl ID		ENSG00000129214	ENSG00000123933
Uniprot IDs		B0FWH2 B0FWH8 I3L145 P04278	Q14582
PDB IDs		1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW 6PYA 6PYB 6PYF 6ULB
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Protease Binding Cell-cell Junction Fructose Biosynthetic Process Detoxification Of Copper Ion Extracellular Space Glucose 6-phosphate:phosphate Antiporter Activity Cellular Response To Cadmium Ion Lamellipodium Cellular Response To Zinc Ion Cellular Response To Copper Ion Mesenchyme Migration Glucose-6-phosphate Transport Negative Regulation Of Cardiac Muscle Contraction Intracellular Zinc Ion Homeostasis Prostaglandin Metabolic Process Prostanoid Metabolic Process Response To Copper Ion Rough Endoplasmic Reticulum Hexose Metabolic Process Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Striated Muscle Contraction Response To Cadmium Ion Cell-cell Junction Organization Caveola Assembly Carbohydrate Metabolic Process Monosaccharide Metabolic Process Plasma Membrane Raft Assembly Response To Zinc Ion	Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Cellular Response To Tert-butyl Hydroperoxide Response To Methylglyoxal Myc-Max Complex Negative Regulation Of RNA Metabolic Process Mad-Max Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Meiotic Sister Chromatid Cohesion Protein Dimerization Activity DNA-binding Transcription Factor Binding Androgen Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Meiotic Cohesin Complex Mediator Complex Binding Regulation Of Nucleobase-containing Compound Metabolic Process Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Cellular Response To Dopamine Transcription Corepressor Activity Establishment Of Sister Chromatid Cohesion Response To Dopamine Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Hydroperoxide DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Biosynthetic Process Negative Regulation Of Circadian Rhythm Regulation Of Transcription By RNA Polymerase II Lateral Element Negative Regulation Of Macromolecule Metabolic Process Protein Heterodimerization Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Mitotic Sister Chromatid Cohesion Cellular Response To Catecholamine Stimulus Negative Regulation Of Metabolic Process Dynein Complex Binding Sin3-type Complex Response To Catecholamine Response To Hydroperoxide Cerebral Cortex Neuron Differentiation
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