SHBG and CLDN4

Number of citations of the paper that reports this interaction (PMID 15862967)
1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SHBG	CLDN4
Gene Name		sex hormone-binding globulin	claudin 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Tight Junction Basal Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane
	Molecular Function	Androgen Binding	Transmembrane Signaling Receptor Activity Structural Molecule Activity Identical Protein Binding
	Biological Process	Primary Spermatocyte Growth	Signal Transduction Female Pregnancy Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Response To Progesterone Establishment Of Skin Barrier
Pathways			Cell junction organization Cell-cell junction organization Tight junction interactions
Drugs
Diseases
GWAS		Androgen levels ( 22936694) Protein quantitative trait loci ( 18464913) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597)
Protein-Protein Interactions		62 interactors: A2M ACPP ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5A1 AZGP1 C9orf24 CD177 CECR5 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A	4 interactors: EPHA2 SHBG TJP1 WNK4
Entrez ID		6462	1364
HPRD ID		01646	04218
Ensembl ID		ENSG00000129214	ENSG00000189143
Uniprot IDs		B0FWH2 B4DYU0 I3L1J1 I3L2X4 P04278	O14493 Q75L80
PDB IDs		1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW
Enriched GO Terms of Interacting Partners?		Platelet Activation Extracellular Matrix Disassembly Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cellular Response To Zinc Ion Endocytosis Vesicle-mediated Transport Response To Wounding Transport Endosomal Transport Cell Activation Response To Zinc Ion Cell Projection Organization Immune System Process MRNA Transcription From RNA Polymerase II Promoter Glucose Metabolic Process MRNA Transcription Neuron Projection Development Movement Of Cell Or Subcellular Component Cellular Response To Cadmium Ion Regulation Of Water Loss Via Skin Formation Of Translation Preinitiation Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cell Morphogenesis Involved In Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Receptor-mediated Endocytosis Hexose Metabolic Process Neuron Development Extracellular Matrix Organization Viral Process Cytoplasmic Sequestering Of Protein Regulation Of Defense Response To Virus By Virus Extracellular Structure Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Axon Development Antigen Processing And Presentation Of Peptide Antigen Locomotion Negative Regulation Of Growth Monosaccharide Metabolic Process Sperm Entry Negative Regulation Of T Cell Migration Contractile Actin Filament Bundle Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Positive Regulation Of Late Endosome To Lysosome Transport Sorbitol Catabolic Process L-xylitol Metabolic Process L-xylitol Catabolic Process Fructose Biosynthetic Process	Cell-cell Signaling Involved In Cell-cell Junction Organization Primary Spermatocyte Growth Notochord Cell Development Epithelium Development Epithelial Cell Development Distal Tubule Morphogenesis Axial Mesoderm Formation Response To Magnetism Renal Sodium Ion Absorption Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport Notochord Formation Axial Mesoderm Morphogenesis Lens Fiber Cell Morphogenesis Establishment Of Endothelial Intestinal Barrier Tissue Development Axial Mesoderm Development Epithelial Tube Morphogenesis Cell Development Intracellular Signal Transduction Anatomical Structure Development Notochord Morphogenesis Tube Morphogenesis Renal Absorption Distal Tubule Development Activation Of Rac GTPase Activity Negative Regulation Of Vascular Permeability Morphogenesis Of An Epithelium Developmental Process Epithelial Cell Differentiation Lens Fiber Cell Development Post-anal Tail Morphogenesis Mammary Gland Epithelial Cell Proliferation Notochord Development Anatomical Structure Morphogenesis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Lamellipodium Assembly Positive Regulation Of Protein Localization To Plasma Membrane Tissue Morphogenesis Establishment Of Endothelial Barrier Hippo Signaling Lens Morphogenesis In Camera-type Eye Tube Development Regulation Of Vascular Permeability Lens Fiber Cell Differentiation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Protein Kinase B Signaling Activation Of Rho GTPase Activity Protein Kinase B Signaling
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi	acta2 cdh1 cdkn1a cldn1 cldn7 ctnnb1 fn1 krt19 mapk1 mapk14 mapk3 mki67 mmp2 mmp9 muc5ac muc6 nes pdac pdacs ptgs2 rps6 rps6kb1 smad4 stains surprising synchronous tgfb1 tgfbr1 vim
Tagcloud (Difference) ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi	acta2 cdh1 cdkn1a cldn1 cldn7 ctnnb1 fn1 krt19 mapk1 mapk14 mapk3 mki67 mmp2 mmp9 muc5ac muc6 nes pdac pdacs ptgs2 rps6 rps6kb1 smad4 stains surprising synchronous tgfb1 tgfbr1 vim
Tagcloud (Intersection) ?