SHBG and APOD

Number of citations of the paper that reports this interaction (PMID 15862967)
1

Data Source:
BioGRID (two hybrid)

		SHBG	APOD
Gene Name		sex hormone-binding globulin	apolipoprotein D
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Cytosolic Ribosome Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Androgen Binding	Lipid Transporter Activity Protein Binding Cholesterol Binding
	Biological Process	Primary Spermatocyte Growth	Response To Reactive Oxygen Species Angiogenesis Glucose Metabolic Process Lipid Metabolic Process Lipid Transport Brain Development Aging Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Tissue Regeneration Negative Regulation Of Protein Import Into Nucleus Response To Drug Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of T Cell Migration
Pathways			Transport of vitamins, nucleosides, and related molecules SLC-mediated transmembrane transport Transport of fatty acids Orphan transporters
Drugs
Diseases
GWAS		Androgen levels ( 22936694) Protein quantitative trait loci ( 18464913) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597)
Protein-Protein Interactions		62 interactors: A2M ACPP ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5A1 AZGP1 C9orf24 CD177 CECR5 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A	5 interactors: APOA2 LEPR POLR2M SHBG VAPA
Entrez ID		6462	347
HPRD ID		01646	00134
Ensembl ID		ENSG00000129214	ENSG00000189058
Uniprot IDs		B0FWH2 B4DYU0 I3L1J1 I3L2X4 P04278	P05090
PDB IDs		1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW	2APD 2HZQ 2HZR
Enriched GO Terms of Interacting Partners?		Platelet Activation Extracellular Matrix Disassembly Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cellular Response To Zinc Ion Endocytosis Vesicle-mediated Transport Response To Wounding Transport Endosomal Transport Cell Activation Response To Zinc Ion Cell Projection Organization Immune System Process MRNA Transcription From RNA Polymerase II Promoter Glucose Metabolic Process MRNA Transcription Neuron Projection Development Movement Of Cell Or Subcellular Component Cellular Response To Cadmium Ion Regulation Of Water Loss Via Skin Formation Of Translation Preinitiation Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cell Morphogenesis Involved In Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Receptor-mediated Endocytosis Hexose Metabolic Process Neuron Development Extracellular Matrix Organization Viral Process Cytoplasmic Sequestering Of Protein Regulation Of Defense Response To Virus By Virus Extracellular Structure Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Axon Development Antigen Processing And Presentation Of Peptide Antigen Locomotion Negative Regulation Of Growth Monosaccharide Metabolic Process Sperm Entry Negative Regulation Of T Cell Migration Contractile Actin Filament Bundle Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Positive Regulation Of Late Endosome To Lysosome Transport Sorbitol Catabolic Process L-xylitol Metabolic Process L-xylitol Catabolic Process Fructose Biosynthetic Process	Negative Regulation Of Growth Hormone Receptor Signaling Pathway Maintenance Of ER Location Primary Spermatocyte Growth Negative Regulation Of Cholesterol Transporter Activity Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Regulation Of Cholesterol Transporter Activity Negative Regulation Of Cholesterol Import Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Endoplasmic Reticulum Localization Regulation Of Cholesterol Import Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Process Diacylglycerol Catabolic Process Steroid Metabolic Process High-density Lipoprotein Particle Clearance Regulation Of Intestinal Cholesterol Absorption Protein Oxidation Lipid Metabolic Process Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process High-density Lipoprotein Particle Assembly Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Cholesterol Esterification Peptidyl-methionine Modification Alcohol Metabolic Process Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Triglyceride-rich Lipoprotein Particle Remodeling Negative Regulation Of Gluconeogenesis Phospholipid Efflux Regulation Of Interleukin-8 Biosynthetic Process Low-density Lipoprotein Particle Remodeling Negative Regulation Of Hydrolase Activity Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Negative Regulation Of Lipase Activity Reverse Cholesterol Transport Diacylglycerol Metabolic Process Regulation Of Protein Localization To Cell Surface Positive Regulation Of Viral Genome Replication COPII-coated Vesicle Budding Regulation Of Viral Release From Host Cell Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Lipid Transport
Tagcloud ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi	a4 antitrypsin apoa apoc apof apoh apoj apol apolipoproteins apom atherogenic carry chd convincingly delipidation dense differs fibrinogen ldl lysosome originate paraoxonase prenylcysteine proteome sdldl strengthens subfractions transthyretin vldl
Tagcloud (Difference) ?		asgr assigned chr distances f1 grin grin1 grin2a grin2b grin2c grin2d grm grm1 grm2 grm3 grm4 grm5 grm6 linkage maps metabotropic mmyhse myhse ppy rr24 shr symbol wtc zi	a4 antitrypsin apoa apoc apof apoh apoj apol apolipoproteins apom atherogenic carry chd convincingly delipidation dense differs fibrinogen ldl lysosome originate paraoxonase prenylcysteine proteome sdldl strengthens subfractions transthyretin vldl
Tagcloud (Intersection) ?